3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-
CAS No.:488808-14-6
Molecular Formula:C26H47NO5
Molecular Weight:453.663
Hs Code.:

Synonyms:

Suppliers and Price of 3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

There total 1 articles about 3-Oxazolidinecarboxylic acid, 4-[(1R,4S)-1,4-dihydroxy-2-hexadecynyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6064-48-8
1-hydroxy-2(E)-pentadecene

: 488808-14-6
N-tert-butoxycarbonyl-(4S,1'R,4'S)-4-[1',4'-dihydroxy-2'-hexadecynyl]-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 88 percent / PPh₃; N-chlorosuccinimide / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: 88 percent / AD-mix-α; MeSO2NH2; NaHCO3 / 2-methyl-propan-2-ol; H2O / 8 h / 0 °C

3.1: 98 percent / p-TsOH / CH₂Cl₂ / 2 h / 20 °C

4.1: hexamethylphosphoramide; n-BuLi / tetrahydrofuran; hexane / 1 h / -42 - 20 °C

5.1: 97 percent / imidazole / dimethylformamide / 20 °C

6.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 71 percent / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

7.1: 91 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; AD-mix-α; N-chloro-succinimide; n-butyllithium; methanesulfonamide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Mitsunobu reaction;
DOI:10.1021/jo026240+

Reference yield:

: 488808-14-6
N-tert-butoxycarbonyl-(4S,1'R,4'S)-4-[1',4'-dihydroxy-2'-hexadecynyl]-2,2-dimethyl-1,3-oxazolidine

: 958020-49-0
(2S,4R,5S,3'S)-5-tert-butoxycarbamido-4-(3'-hydroxypentadecyl)-2-phenyl-1,3-dioxacyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.93 g / hydrogen / Pd(OH)2 / ethyl acetate / 168 h / 20 °C

2: 93 percent / acetic acid / H₂O / 24 h / 20 °C

3: 87 percent / PPTS / CH₂Cl₂ / 24 h / 20 °C

With hydrogen; pyridinium p-toluenesulfonate; acetic acid; palladium dihydroxide; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tetasy.2007.08.028

Reference yield:

: 488808-14-6
N-tert-butoxycarbonyl-(4S,1'R,4'S)-4-[1',4'-dihydroxy-2'-hexadecynyl]-2,2-dimethyl-1,3-oxazolidine

: C₃₁H₅₃O₇NS

Guidance literature:: Multi-step reaction with 4 steps

1: 1.93 g / hydrogen / Pd(OH)2 / ethyl acetate / 168 h / 20 °C

2: 93 percent / acetic acid / H₂O / 24 h / 20 °C

3: 87 percent / PPTS / CH₂Cl₂ / 24 h / 20 °C

4: pyridine / 48 h / 4 °C

With pyridine; hydrogen; pyridinium p-toluenesulfonate; acetic acid; palladium dihydroxide; In dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tetasy.2007.08.028