Bicyclo[3.1.0]hexane-6-carboxylic acid, 2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl] -2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)-

Base Information

Chemical Name:Bicyclo[3.1.0]hexane-6-carboxylic acid, 2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl] -2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)-
CAS No.:488859-30-9
Molecular Formula:C27H32N2O7
Molecular Weight:496.56
Hs Code.:

Bicyclo[3.1.0]hexane-6-carboxylic acid,
2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl]
-2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)-

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Chemical Property of Bicyclo[3.1.0]hexane-6-carboxylic acid, 2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl] -2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)-

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Technology Process of Bicyclo[3.1.0]hexane-6-carboxylic acid, 2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl] -2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)-

There total 3 articles about Bicyclo[3.1.0]hexane-6-carboxylic acid, 2-[[[(1S)-2-oxo-1-(phenylmethyl)-2-(2-propenyloxy)ethyl]amino]carbonyl] -2-[[(2-propenyloxy)carbonyl]amino]-, 2-propenyl ester, (1S,2S,5R,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176199-48-7,176027-90-0,176199-49-8,177317-28-1,207553-80-8,597540-64-2
eglumetad

: 488859-30-9
(1S,2S,5R,6S)-2-allyloxycarbonylamino-2-[(1'S)-allyloxycarbonyl-2'-phenylethyl]carbamoylbicyclo[3.1.0]hexane-6-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / dioxane / 20 °C

2: 6.8 g / N-ethyl-N'-dimethylaminopropylcarbodiimide; (dimethylamino)pyridine / CH₂Cl₂ / 20 °C

3: N-ethyl-N'-dimethylaminopropylcarbodiimide; (dimethylamino)pyridine; N-hydroxybenzotriazole / triethylamine / CH₂Cl₂ / 20 °C

With dmap; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm050235r

Reference yield:

: 488859-05-8
(1S,2S,5R,6S)-2-allyloxycarbonylaminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid 6-allyl ester

: 88223-99-8
L-phenylalanine allyl ester

: 488859-30-9
(1S,2S,5R,6S)-2-allyloxycarbonylamino-2-[(1'S)-allyloxycarbonyl-2'-phenylethyl]carbamoylbicyclo[3.1.0]hexane-6-carboxylic acid allyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm050235r

Reference yield:

: 488859-03-6
(1S,2S,5R,6S)-2-Allyloxycarbonylamino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

: 488859-30-9
(1S,2S,5R,6S)-2-allyloxycarbonylamino-2-[(1'S)-allyloxycarbonyl-2'-phenylethyl]carbamoylbicyclo[3.1.0]hexane-6-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 6.8 g / N-ethyl-N'-dimethylaminopropylcarbodiimide; (dimethylamino)pyridine / CH₂Cl₂ / 20 °C

2: N-ethyl-N'-dimethylaminopropylcarbodiimide; (dimethylamino)pyridine; N-hydroxybenzotriazole / triethylamine / CH₂Cl₂ / 20 °C

With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1021/jm050235r