Benzenesulfonamide, N-[(1S)-1-(cyanomethyl)-2-[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-imidaz ol-4-yl]ethyl]-2,4,6-trimethyl-

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Chemical Name:Benzenesulfonamide, N-[(1S)-1-(cyanomethyl)-2-[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-imidaz ol-4-yl]ethyl]-2,4,6-trimethyl-
CAS No.:489417-68-7
Molecular Formula:C25H30N4O4S2
Molecular Weight:514.67
Hs Code.:
Mol file:489417-68-7.mol

Synonyms:

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Chemical Property of Benzenesulfonamide, N-[(1S)-1-(cyanomethyl)-2-[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-imidaz ol-4-yl]ethyl]-2,4,6-trimethyl-

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Technology Process of Benzenesulfonamide, N-[(1S)-1-(cyanomethyl)-2-[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-imidaz ol-4-yl]ethyl]-2,4,6-trimethyl-

There total 5 articles about Benzenesulfonamide, N-[(1S)-1-(cyanomethyl)-2-[1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-imidaz ol-4-yl]ethyl]-2,4,6-trimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 143-33-9,25596-52-5
sodium cyanide

: 489417-64-3
4-[3-(methanesulfonyloxy)-2-(2,4,6-trimethylbenzenesulfonamido)propyl]-1-(2,4,6-trimethylbenzenesulfonyl)imidazole

: 489417-68-7
(S)-3-(2,4,6-trimethylbenzenesulfonamido)-4-[1-(2,4,6-trimethylbenzenesulfonyl)-imidazol-4-yl]butanonitrile

Guidance literature:: With sodium cyanide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(02)01587-3

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 489417-68-7
(S)-3-(2,4,6-trimethylbenzenesulfonamido)-4-[1-(2,4,6-trimethylbenzenesulfonyl)-imidazol-4-yl]butanonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / triethylamine / CHCl₃

2: 58 percent / NaBH₄ / methanol / 1.5 h / 0 °C

3: 81 percent / triethylamine / ethyl acetate / 1.5 h / 20 °C

4: 63 percent / NaCN / dimethylformamide / 24 h / 20 °C

With sodium tetrahydroborate; sodium cyanide; triethylamine; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01587-3

Reference yield:

: 7389-87-9
L-histidine methyl ester dihydrochloride

: 489417-68-7
(S)-3-(2,4,6-trimethylbenzenesulfonamido)-4-[1-(2,4,6-trimethylbenzenesulfonyl)-imidazol-4-yl]butanonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / triethylamine / CHCl₃

2: 58 percent / NaBH₄ / methanol / 1.5 h / 0 °C

3: 81 percent / triethylamine / ethyl acetate / 1.5 h / 20 °C

4: 63 percent / NaCN / dimethylformamide / 24 h / 20 °C

With sodium tetrahydroborate; sodium cyanide; triethylamine; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01587-3