Technology Process of 1,2-Pyrrolidinedicarboxylic acid,
4-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester,
(2R,4S)-
There total 6 articles about 1,2-Pyrrolidinedicarboxylic acid,
4-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1-(phenylmethyl) ester,
(2R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / acetone / 4 h / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
3: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere
4: triphenylphosphine; water / tetrahydrofuran
5: sodium hydrogencarbonate / water; 1,4-dioxane / 4 h
6: lithium hydroxide; water / tetrahydrofuran / 1 h
With
sodium azide; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
4: |Staudinger Azide Reduction;
DOI:10.1002/pep2.24140
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetic acid; acetic anhydride / 6 h / Reflux
1.2: 3 h / Reflux
2.1: sodium hydrogencarbonate / water; toluene / 12.5 h / 20 °C
3.1: potassium carbonate / acetone / 4 h / Inert atmosphere; Reflux
4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.1: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere
6.1: triphenylphosphine; water / tetrahydrofuran
7.1: sodium hydrogencarbonate / water; 1,4-dioxane / 4 h
8.1: lithium hydroxide; water / tetrahydrofuran / 1 h
With
sodium azide; water; acetic anhydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;
6.1: |Staudinger Azide Reduction;
DOI:10.1002/pep2.24140
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; water / tetrahydrofuran
2: sodium hydrogencarbonate / water; 1,4-dioxane / 4 h
3: lithium hydroxide; water / tetrahydrofuran / 1 h
With
water; sodium hydrogencarbonate; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; water;
1: |Staudinger Azide Reduction;
DOI:10.1002/pep2.24140
