1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide

Base Information

Chemical Name:1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide
CAS No.:489446-84-6
Molecular Formula:C24H28N4O
Molecular Weight:388.513
Hs Code.:
DSSTox Substance ID:DTXSID401146493
ChEMBL ID:CHEMBL360352
Mol file:489446-84-6.mol

Synonyms:CHEMBL360352;SCHEMBL1315954;WOPRDVHBRJFDQW-UHFFFAOYSA-N;DTXSID401146493;BDBM50161555;1-Methyl-4,5-di-p-tolyl-1H-imidazole-2-carboxylic acid piperidin-1-ylamide;1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide;N-(Piperidin-1-yl)-4,5-di(4-methylphenyl)-1-methylimidazole-2-carboxamide;N-(piperidin-1-yl)-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide;489446-84-6

Suppliers and Price of 1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:388.22631153
Heavy Atom Count:29
Complexity:533

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=C(N(C(=N2)C(=O)NN3CCCCC3)C)C4=CC=C(C=C4)C

Technology Process of 1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide

There total 4 articles about 1-methyl-N-(piperidin-1-yl)-4,5-dip-tolyl-1H-imidazole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1218-89-9
4,4'-dimethylbenzoin

: 489446-84-6
N-(piperidin-1-yl)-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethane-1,2-diol / 1.5 h / 180 °C

2.1: POCl₃ / 16 h / 100 °C

3.1: n-BuLi / tetrahydrofuran / 1.5 h / -70 - -20 °C

3.2: tetrahydrofuran / -20 - 20 °C

4.1: 100 percent / H₂ / Pd/C / methanol / 2585.74 Torr

5.1: Py-BOP / CH₂Cl₂ / 20 °C

With n-butyllithium; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethylene glycol;
DOI:10.1016/j.bmcl.2004.12.078

Reference yield:

: 489446-65-3
4,5-di-(4-methylphenyl)-1-methyl-(1H),(3H)-imidazolin-2-one

: 489446-84-6
N-(piperidin-1-yl)-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: POCl₃ / 16 h / 100 °C

2.1: n-BuLi / tetrahydrofuran / 1.5 h / -70 - -20 °C

2.2: tetrahydrofuran / -20 - 20 °C

3.1: 100 percent / H₂ / Pd/C / methanol / 2585.74 Torr

4.1: Py-BOP / CH₂Cl₂ / 20 °C

With n-butyllithium; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.12.078

Reference yield:

: 489446-66-4
2-Chloro-4,5-di-(4-methylphenyl)-1-methylimidazole

: 489446-84-6
N-(piperidin-1-yl)-4,5-di-(4-methylphenyl)-1-methylimidazole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran / 1.5 h / -70 - -20 °C

1.2: tetrahydrofuran / -20 - 20 °C

2.1: 100 percent / H₂ / Pd/C / methanol / 2585.74 Torr

3.1: Py-BOP / CH₂Cl₂ / 20 °C

With n-butyllithium; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.12.078