1-Benzyl-3,3-dimethyl-4-phenylazetidine-2-one

Base Information

• Chemical Name: 1-Benzyl-3,3-dimethyl-4-phenylazetidine-2-one
• CAS No.: 7468-30-6
• Molecular Formula: C18H19NO
• Molecular Weight: 265.355
• Hs Code.: 2933790090
• Mol file: 7468-30-6.mol

Synonyms:2-Azetidinone,3-dimethyl-4-phenyl;2-Azetidinone,1-benzyl-3,3-dimethyl-4-phenyl;

Chemical Property of 1-Benzyl-3,3-dimethyl-4-phenylazetidine-2-one

Chemical Property:

• Vapor Pressure: 1.02E-07mmHg at 25°C
• Boiling Point: 433.5°C at 760 mmHg
• Flash Point: 176.3°C
• PSA: 20.31000
• Density: 1.108g/cm³
• LogP: 3.73420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-3,3-dimethyl-4-phenylazetidine-2-one

There total 9 articles about 1-Benzyl-3,3-dimethyl-4-phenylazetidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 2-bromoisobutyrate (600-00-0) + (E)-N-benzylidenebenzylamine (27845-50-7) → 1-benzyl-3,3-dimethyl-4-phenyl-2-azetidinone (7468-30-6)

Guidance literature:

With iodine; zinc; In 1,4-dioxane; at 20 ℃; for 0.0833333h; sonication;

DOI:10.1016/j.tet.2004.01.002

Reference yield: 82.0%

2-benzyl-4-methyl-1-phenyl-3-oxo-6-thia-2-azabicyclo<2.2.0>hexane (88296-01-9) → 1-benzyl-3,3-dimethyl-4-phenyl-2-azetidinone (7468-30-6)

Guidance literature:

With hydrogen; nickel;

DOI:10.1021/jo00176a040

Reference yield:

dimethylketene (598-26-5) + N-benzylidene benzylamine (780-25-6) → 1-benzyl-3,3-dimethyl-4-phenyl-2-azetidinone (7468-30-6)

Guidance literature:

With diethyl ether;

upstream raw materials:

3-benzylamino-2,2-dimethyl-3-phenyl-propionic acid

3-(benzyl-isobutyryl-amino)-2,2-dimethyl-3-phenyl-propionic acid

dimethylketene

N-benzylidene benzylamine

Downstream raw materials:

3-benzylamino-2,2-dimethyl-3-phenyl-propionic acid

1-benzyl-3,3-dimethyl-2-phenylazetidine