2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine

Base Information

• Chemical Name: 2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine
• CAS No.: 138335-88-3
• Molecular Formula: C12H12Br2N4
• Molecular Weight: 372.0585
• Mol file: 138335-88-3.mol

Synonyms:2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine;138335-88-3

Chemical Property of 2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine

Chemical Property:

• Vapor Pressure: 3.13E-08mmHg at 25°C
• Boiling Point: 448.3°C at 760 mmHg
• Flash Point: 224.9°C
• Density: 1.72g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 371.94082
• Heavy Atom Count: 18
• Complexity: 323

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=N1)C(=CC2=C(N=C(N2C)Br)Br)C
• Isomeric SMILES: CC1=CN=C(C=N1)/C(=C/C2=C(N=C(N2C)Br)Br)/C

Technology Process of 2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine

There total 2 articles about 2-((E)-1-(2,5-Dibromo-3-methylimidazol-4-yl)prop-1-en-2-yl)-5-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-2-(5-methyl-pyrazin-2-yl)-propan-1-ol (138335-80-5,138335-81-6) → 2-[(E)-2-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-1-methyl-vinyl]-5-methyl-pyrazine (138335-88-3)

Guidance literature:

With methanesulfonic acid; In toluene; Yield given; Heating;

DOI:10.1021/jo00031a017

Reference yield:

1-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-2-(5-methyl-pyrazin-2-yl)-propan-1-one (138335-78-1) → 2-[(E)-2-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-1-methyl-vinyl]-5-methyl-pyrazine (138335-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borohydride

2: methanesulfonic acid / toluene / Heating

With sodium tetrahydroborate; methanesulfonic acid; In toluene;

DOI:10.1021/jo00031a017

Reference yield: 95.0%

2-[(E)-2-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-1-methyl-vinyl]-5-methyl-pyrazine (138335-88-3) → 2-Bromo-3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (138336-14-8)

Guidance literature:

With potassium tert-butylate; for 0.25h; Irradiation;

DOI:10.1021/jo00031a017

upstream raw materials:

1-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-2-(5-methyl-pyrazin-2-yl)-propan-1-ol

1-(2,5-Dibromo-3-methyl-3H-imidazol-4-yl)-2-(5-methyl-pyrazin-2-yl)-propan-1-one

Downstream raw materials:

2-Bromo-3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxaline