3H-1,2,4-Triazol-3-one, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol -1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]-

Base Information

Chemical Name:3H-1,2,4-Triazol-3-one, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol -1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]-
CAS No.:492450-12-1
Molecular Formula:C27H24F2N6O3
Molecular Weight:518.523
Hs Code.:

3H-1,2,4-Triazol-3-one,
2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol
-1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]-

Synonyms:

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Chemical Property of 3H-1,2,4-Triazol-3-one, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol -1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]-

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Technology Process of 3H-1,2,4-Triazol-3-one, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol -1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]-

There total 4 articles about 3H-1,2,4-Triazol-3-one, 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol -1-yl)propyl]-2,4-dihydro-4-[4-(phenylmethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616897-41-7
4-(4-(benzyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 492450-12-1
(1R,2R)-4-(4-benzyloxyphenyl)-2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazole)-1-yl-propyl]-1,2,4-triazol-3-one

Guidance literature:: 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole; With sodium hydride; In dimethyl sulfoxide; at 50 ℃; for 1h;

4-(4-(benzyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; In dimethyl sulfoxide; at 80 ℃; for 0.5h;

Reference yield:

: 616897-41-7
4-(4-(benzyloxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 492450-12-1
(1R,2R)-4-(4-benzyloxyphenyl)-2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazole)-1-yl-propyl]-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropyl azodicarboxylate; triphenyphosphine / dimethylformamide / 0 - 30 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; 1: Mitsunobu coupling;
DOI:10.1080/00397910500297461

Reference yield:

: 126918-33-0
(1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

: 492450-12-1
(1R,2R)-4-(4-benzyloxyphenyl)-2-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazole)-1-yl-propyl]-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropyl azodicarboxylate; triphenyphosphine / dimethylformamide / 0 - 30 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; 1: Mitsunobu coupling;
DOI:10.1080/00397910500297461