2-Propen-1-one, 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenyl-

Base Information

Chemical Name:2-Propen-1-one, 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenyl-
CAS No.:494205-23-1
Molecular Formula:C22H18O3
Molecular Weight:330.383
Hs Code.:

Synonyms:

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Chemical Property of 2-Propen-1-one, 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenyl-

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Technology Process of 2-Propen-1-one, 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenyl-

There total 6 articles about 2-Propen-1-one, 1-[2-hydroxy-4-(phenylmethoxy)phenyl]-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (3R,4R)-4-Benzenesulfonyl-7-benzyloxy-3-phenyl-chroman

: 494205-23-1
1-(4-benzyloxy-2-hydroxy-phenyl)-2-phenyl-propenone

Guidance literature:: (3R,4R)-4-Benzenesulfonyl-7-benzyloxy-3-phenyl-chroman; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

With MoO₅*pyridine*HMPA; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(02)01653-2

Reference yield:

: 76240-25-0
7-benzyloxy-2H-1-benzopyran

: 494205-23-1
1-(4-benzyloxy-2-hydroxy-phenyl)-2-phenyl-propenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: HgCl₂ / methanol; CH₂Cl₂ / 20 °C

1.2: DBU / tetrahydrofuran / 20 °C

2.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 53 percent / tetrahydrofuran / -78 - -30 °C

3.1: LHMDS / tetrahydrofuran / -78 °C

3.2: 70 percent / MoOPH / tetrahydrofuran / -78 °C

With n-butyllithium; mercury dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/S0040-4039(02)01653-2

Reference yield:

: 100-44-7
benzyl chloride

: 494205-23-1
1-(4-benzyloxy-2-hydroxy-phenyl)-2-phenyl-propenone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethylsulfoxide / 20 °C

1.2: 55 percent / aq. KOH / 16 h / 90 °C

2.1: NaH / dimethylformamide / 0 - 20 °C

2.2: 93 percent / 20 °C

3.1: 75 percent / p-TsOH / dioxane / 110 °C

4.1: HgCl₂ / methanol; CH₂Cl₂ / 20 °C

4.2: DBU / tetrahydrofuran / 20 °C

5.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

5.2: 53 percent / tetrahydrofuran / -78 - -30 °C

6.1: LHMDS / tetrahydrofuran / -78 °C

6.2: 70 percent / MoOPH / tetrahydrofuran / -78 °C

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; mercury dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01653-2