Janex-1

Base Information

Chemical Name:Janex-1
CAS No.:202475-60-3
Molecular Formula:C16H15N3O3
Molecular Weight:297.313
Hs Code.:
UNII:1J8Q49TR3I
DSSTox Substance ID:DTXSID301226692
Nikkaji Number:J976.378C
ChEMBL ID:CHEMBL405130

Synonyms:4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline;JANEX-1;WHI P131;WHI-P131

Suppliers and Price of Janex-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
WHI-P131
5mg
$ 350.00

Usbiological
WHI-P 131
100mg
$ 1380.00

TRC
Janex1
1mg
$ 45.00

Medical Isotopes, Inc.
Janex1
25 mg
$ 875.00

Matrix Scientific
4-(6,7-Dimethoxyquinazolin-4-ylamino)phenol 95%
5g
$ 6383.00

Matrix Scientific
4-(6,7-Dimethoxyquinazolin-4-ylamino)phenol 95%
1g
$ 2128.00

DC Chemicals
WHI-P131(Janex1) >98%
250 mg
$ 650.00

DC Chemicals
WHI-P131(Janex1) >98%
1 g
$ 1300.00

DC Chemicals
WHI-P131(Janex1) >98%
100 mg
$ 350.00

Crysdot
JANEX-1 98+%
50mg
$ 391.00

Total 24 raw suppliers

Chemical Property of Janex-1

Chemical Property:

Boiling Point:468.1±40.0 °C(Predicted)
PKA:10.06±0.26(Predicted)
PSA：76.50000
Density:1.336±0.06 g/cm3(Predicted)
LogP:3.16920
Storage Temp.:2-8°C
Solubility.:DMSO: 18 mg/mL, soluble
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:297.11134135
Heavy Atom Count:22
Complexity:350

Purity/Quality:

99%, ^*data from raw suppliers

WHI-P131 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
Description WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5
Uses Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.

Technology Process of Janex-1

There total 6 articles about Janex-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 123-30-8
4-amino-phenol

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 202475-60-3
WHI-P₁₃₁

Guidance literature:: In isopropyl alcohol; at 85 ℃; for 2h;

Reference yield: 84.29%

: 202475-60-3
WHI-P₁₃₁

Guidance literature:

Reference yield:

: 5004-88-6
4,5-dimethoxyanthranilamide

: 202475-60-3
WHI-P₁₃₁

Guidance literature:: Multi-step reaction with 3 steps

1: 1.18 g / 5 h / Heating

2: 83 percent / phosphorus oxychloride / 4 h / Heating

3: 84.29 percent / Et₃N / methanol / Heating

With triethylamine; trichlorophosphate; In methanol;
DOI:10.1097/00005344-200002000-00002