Technology Process of Cyclopropanebutanoic acid,
1-[2-[(2R)-2-[(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-
5-oxo-1-pyrrolidinyl]ethyl]-
There total 15 articles about Cyclopropanebutanoic acid,
1-[2-[(2R)-2-[(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-
5-oxo-1-pyrrolidinyl]ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C26H37NO5;
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
Cooling with ice;
DOI:10.1248/cpb.59.1494
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole; iodine; triphenylphosphine / benzene / 0.5 h / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere
2.2: 50 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
4.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C
4.2: Cooling with ice
With
1H-imidazole; tetrabutyl ammonium fluoride; iodine; sodium hydride; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil; benzene;
DOI:10.1248/cpb.59.1494
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / methanol / 17 h / 20 °C / Inert atmosphere
2.1: diethylzinc / hexane; dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: 1H-imidazole; iodine; triphenylphosphine / benzene / 0.5 h / 20 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere
4.2: 50 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
6.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C
6.2: Cooling with ice
With
1H-imidazole; tetrabutyl ammonium fluoride; iodine; diethylzinc; sodium hydride; potassium carbonate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil; benzene;
2.1: Simmons-Smith reaction;
DOI:10.1248/cpb.59.1494
