Technology Process of 5-Heptenoic acid,
7-[(2R)-2-[(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-5-
oxo-1-pyrrolidinyl]-, (5Z)-
There total 11 articles about 5-Heptenoic acid,
7-[(2R)-2-[(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-5-
oxo-1-pyrrolidinyl]-, (5Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol;
at 20 ℃;
DOI:10.1248/cpb.59.1494
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere
1.2: 1 h / 0 °C / Inert atmosphere
2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 20 °C / Inert atmosphere
3.1: water; sodium hydroxide / tetrahydrofuran; 1,2-dimethoxyethane; ethanol / 20 °C
With
borane-THF; water; sodium hydride; sodium hydroxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; toluene; mineral oil;
1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1248/cpb.59.1494
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / methanol / 4 h / 20 °C
2.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
4.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 20 °C / Inert atmosphere
5.1: water; sodium hydroxide / tetrahydrofuran; 1,2-dimethoxyethane; ethanol / 20 °C
With
borane-THF; water; sulfur trioxide pyridine complex; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; toluene; mineral oil;
3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1248/cpb.59.1494
