Technology Process of 4,6,8-Decatrienoic acid, 2,2,4-trimethyl-3-oxo-10-phenyl-, ethyl ester,
(4E,6E,8E)-
There total 5 articles about 4,6,8-Decatrienoic acid, 2,2,4-trimethyl-3-oxo-10-phenyl-, ethyl ester,
(4E,6E,8E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
triethyl 2,2-dimethyl-3-oxo-4-phosphonopentanoate;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.16667h;
(E)-3-(tri-n-butylstannyl)-2-propenal;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 21h;
1-iodo-3-phenylpropene;
dichloro bis(acetonitrile) palladium(II);
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5.5h;
Further stages.;
DOI:10.1039/b306925g
- Guidance literature:
-
(E)-3-(tri-n-butylstannyl)-2-propenal; triethyl 2,2-dimethyl-3-oxo-4-phosphonopentanoate;
With
sodium hydride;
In
tetrahydrofuran;
(E)-1-iodo-3-phenyl-1-propene;
dichloro bis(acetonitrile) palladium(II);
In
N,N-dimethyl-formamide;
DOI:10.1055/s-2002-34905
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran / 1.17 h / 0 - 20 °C
1.2: 89 percent / tetrahydrofuran / 22 h / 0 - 20 °C
2.1: 82 percent / bromine; AcOH / 3 h / 20 °C
3.1: 89 percent / toluene / 50 h / Heating
4.1: NaH / tetrahydrofuran / 1.17 h / 0 - 20 °C
4.2: tetrahydrofuran / 21 h / 0 - 20 °C
4.3: 211 mg / PdCl2(MeCN)2 / dimethylformamide / 5.5 h / 20 °C
With
bromine; sodium hydride; acetic acid;
In
tetrahydrofuran; toluene;
4.2: Wadsworth-Emmons reaction / 4.3: Stille reaction;
DOI:10.1039/b306925g
