3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Base Information

Chemical Name:3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid
CAS No.:494799-85-8
Molecular Formula:C20H20N2O2
Molecular Weight:320.391
Hs Code.:
Mol file:494799-85-8.mol

Synonyms:3-cyclopentyl-1-methyl-2-(pyridine-2-yl)-1H-indole-6-carboxylic acid;

Suppliers and Price of 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Chemical Property:

Melting Point:237 - 238.5 °C
PSA：55.12000
LogP:4.59610

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

There total 9 articles about 3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 865173-50-8
3-cyclopentyl-2-(2-pyridyl)-N-methylindole-6-carboxylic acid methyl ester

: 494799-85-8
3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm3006788

Reference yield:

: 863886-23-1
3-cyclopentyl-1-methyl-2-tributylstannanyl-1H-indole-6-carboxylic acid methyl ester

: 494799-85-8
3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / dimethyl sulfoxide / 0.67 h / 20 - 75 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere

With sodium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501532z

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 494799-85-8
3-cyclopentyl-1-methyl-2-pyridin-2-yl-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / methanol; water / 21 h / 75 °C / Inert atmosphere

2.1: 20% Pd(OH)2/C; hydrogen / methanol / 18 h / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: bromine; sodium acetate / Isopropyl acetate / 4 - 13 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -71 °C / Inert atmosphere

5.2: -69 - 20 °C / Inert atmosphere

6.1: palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine / tetrahydrofuran; methanol; hexane / 4.5 h / Inert atmosphere; Reflux

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C / Inert atmosphere

With n-butyllithium; 20% Pd(OH)2/C; water; hydrogen; bromine; sodium acetate; palladium diacetate; potassium carbonate; Tri(p-tolyl)phosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; Isopropyl acetate; water; N,N-dimethyl-formamide; 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm3006788