5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-

Base Information

Chemical Name:5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-
CAS No.:494841-90-6
Molecular Formula:C₃₇H₃₉NO₆
Molecular Weight:593.72
Hs Code.:

5H-Cyclopenta[b]pyridine-6-carboxylic acid,
5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy
phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-

Synonyms:

Suppliers and Price of 5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-

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Chemical Property of 5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-

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Technology Process of 5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)-

There total 1 articles about 5H-Cyclopenta[b]pyridine-6-carboxylic acid, 5-(2,3-dihydro-6-benzofuranyl)-6,7-dihydro-7-[4-methoxy-2-[[(4-methoxy phenyl)methoxy]methyl]phenyl]-, 1,1-dimethylethyl ester, (5S,6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (3S)-3-{2-{(RS)-hydroxy[4-methoxy-2-(4-methoxy-benzyloxymethyl)phenyl]methyl}-3-pyridinyl}-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate

: 494841-90-6
5-(2,3-dihydro-benzofuran-6-yl)-7-[4-methoxy-2-(4-methoxy-benzyloxymethyl)-phenyl]-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid tert-butyl ester

Guidance literature:: With diethyl chlorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1248/cpb.50.1066

Reference yield:

: 494841-90-6
5-(2,3-dihydro-benzofuran-6-yl)-7-[4-methoxy-2-(4-methoxy-benzyloxymethyl)-phenyl]-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid tert-butyl ester

: 1026038-00-5
5-(2,3-dihydro-benzofuran-6-yl)-7-[4-methoxy-2-(4-methoxy-benzyloxymethyl)-phenyl]-1-oxy-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid tert-butyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃; for 12h;
DOI:10.1248/cpb.50.1066

Reference yield:

: 494841-90-6
5-(2,3-dihydro-benzofuran-6-yl)-7-[4-methoxy-2-(4-methoxy-benzyloxymethyl)-phenyl]-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid tert-butyl ester

: 494841-92-8
tert-butyl (5S,6R,7R)-(+)-5-(2,3-dihydrobenzo[b]furan-6-yl)-7-(2-hydroxymethyl-4-methoxyphenyl)-2-(N-isopropylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: m-chloroperoxybenzoic acid / CHCl₃ / 12 h / 0 °C

2: 2.60 g / Et₃N / CHCl₃ / 7 h / 70 °C

3: H₂ / Pd(OH)2 / ethyl acetate; methanol / 48 h / 20 °C / 735.51 Torr

4: 1.59 g / DIBAL / tetrahydrofuran; toluene / 1 h / -78 °C

With hydrogen; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform; ethyl acetate; toluene;
DOI:10.1248/cpb.50.1066