2-Propenoic acid, 3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl ]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl ]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)-
CAS No.:494857-17-9
Molecular Formula:C35H36N4O5
Molecular Weight:592.695
Hs Code.:

2-Propenoic acid,
3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl
]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)-

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl ]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)-

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Technology Process of 2-Propenoic acid, 3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl ]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)-

There total 11 articles about 2-Propenoic acid, 3-[4-[[[1-[[[3-cyclopentyl-2-(5-methoxy-2-pyridinyl)-1-methyl-1H-indol-6-yl ]carbonyl]amino]cyclobutyl]carbonyl]amino]phenyl]-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22264-50-2
1-aminocyclobutane-1-carboxylic acid

: 494857-17-9
C₃₅H₃₆N₄O₅

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylenecyclourethane; phosphorus pentachloride / acetonitrile / 22 h / 20 °C / Inert atmosphere

2.1: acetonitrile / 2.5 h / 20 °C / Inert atmosphere

2.2: 0.25 h / Inert atmosphere

3.1: dimethyl sulfoxide / 20 °C / Inert atmosphere

4.1: water / 20 °C / Alkaline conditions; Inert atmosphere

With dimethylenecyclourethane; phosphorus pentachloride; water; In dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm3006788

Reference yield:

: 1670-82-2,261352-47-0
Indole-6-carboxylic acid

: 494857-17-9
C₃₅H₃₆N₄O₅

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol; water / 21 h / 75 °C / Inert atmosphere

2.1: 20% Pd(OH)2/C; hydrogen / methanol / 18 h / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: bromine; sodium acetate / Isopropyl acetate / 4 - 13 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -72 - -68 °C / Inert atmosphere

5.2: -72 - 20 °C / Inert atmosphere

6.1: copper(l) iodide; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 0.75 h / Inert atmosphere

6.2: 2 h / 100 °C / Inert atmosphere

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 60 °C / Inert atmosphere

8.1: dimethyl sulfoxide / 20 °C / Inert atmosphere

9.1: water / 20 °C / Alkaline conditions; Inert atmosphere

With copper(l) iodide; n-butyllithium; 20% Pd(OH)2/C; water; hydrogen; bromine; sodium acetate; potassium carbonate; triphenylphosphine; lithium chloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: |Stille Cross Coupling / 6.2: |Stille Cross Coupling;
DOI:10.1021/jm3006788

Reference yield:

: 120-92-3
cyclopentanone

: 494857-17-9
C₃₅H₃₆N₄O₅

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol; water / 21 h / 75 °C / Inert atmosphere

2.1: 20% Pd(OH)2/C; hydrogen / methanol / 18 h / 760.05 Torr / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: bromine; sodium acetate / Isopropyl acetate / 4 - 13 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / -72 - -68 °C / Inert atmosphere

5.2: -72 - 20 °C / Inert atmosphere

6.1: copper(l) iodide; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 0.75 h / Inert atmosphere

6.2: 2 h / 100 °C / Inert atmosphere

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 60 °C / Inert atmosphere

8.1: dimethyl sulfoxide / 20 °C / Inert atmosphere

9.1: water / 20 °C / Alkaline conditions; Inert atmosphere

With copper(l) iodide; n-butyllithium; 20% Pd(OH)2/C; water; hydrogen; bromine; sodium acetate; potassium carbonate; triphenylphosphine; lithium chloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; Isopropyl acetate; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 6.1: |Stille Cross Coupling / 6.2: |Stille Cross Coupling;
DOI:10.1021/jm3006788