N,O-BIS-(BENZYLOXYCARBONYL)-HYDROXYLAMINE

Base Information

• Chemical Name: N,O-BIS-(BENZYLOXYCARBONYL)-HYDROXYLAMINE
• CAS No.: 4950-01-0
• Molecular Formula: C16H15NO5
• Molecular Weight: 301.29400
• Mol file: 4950-01-0.mol

Synonyms:Cbz-L-Val-O-succinimide;benzyl benzyloxycarbonyloxycarbamate;Z-Val-ONSu;N,O-bis benzyloxycarbonyl hydroxylamine;N-carbobenzoxy-O-carbobenzoxyhydroxylamine;N-Z-L-valine N-hydroxysuccinimide ester;N-benzyloxycarbonyl-L-valine succinimide ester;Z-L-Valine N-hydroxysuccinimide ester;N-Cbz-L-valine Succinimidyl Ester;N-carbobenzoxy-L-valine N-hydroxysuccinimide ester;N-benzoxycarbonyl-L-valine succinimide ester;Z-Val-OSu;

Chemical Property of N,O-BIS-(BENZYLOXYCARBONYL)-HYDROXYLAMINE

Chemical Property:

• PSA: 73.86000
• LogP: 3.57210

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,O-BIS-(BENZYLOXYCARBONYL)-HYDROXYLAMINE

There total 7 articles about N,O-BIS-(BENZYLOXYCARBONYL)-HYDROXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl chloroformate (501-53-1,94274-21-2) → Benzyl N-hydroxycarbamate (3426-71-9) + N,O-bis-benzyloxycarbonyl-hydroxylamine (4950-01-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In dichloromethane; water; at 0 - 4 ℃; for 2h; Product distribution / selectivity;

Reference yield: 52.0%

Benzyl N-hydroxycarbamate (3426-71-9) + benzyl chloroformate (501-53-1,94274-21-2) → N,O-bis-benzyloxycarbonyl-hydroxylamine (4950-01-0)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo051158a

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N,O-bis-benzyloxycarbonyl-hydroxylamine (4950-01-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1016/S0040-4039(01)00234-9

upstream raw materials:

Benzyl N-hydroxycarbamate

benzyl chloroformate

Downstream raw materials:

N,O-bis(benzyloxycarbonyl)-N-[3-(thien-3-yl)prop-2-enyl]hydroxylamine

C₂₁H₂₃NO₅

C₂₂H₂₃NO₅

C₂₄H₂₃NO₅