Methyl 3-Fluoro-4-Morpholinobenzoate

Base Information

• Chemical Name: Methyl 3-Fluoro-4-Morpholinobenzoate
• CAS No.: 495405-04-4
• Molecular Formula: C12H14FNO3
• Molecular Weight: 239.246
• Hs Code.: 2934999090
• Mol file: 495405-04-4.mol

Synonyms:Methyl 3-Fluoro-4-morpholinobenzoate;

Chemical Property of Methyl 3-Fluoro-4-Morpholinobenzoate

Chemical Property:

• PSA: 38.77000
• LogP: 1.51390

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-fluoro-4-morpholinobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-Fluoro-4-Morpholinobenzoate

There total 2 articles about Methyl 3-Fluoro-4-Morpholinobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + methyl 3,4-difluorobenzoate (369-25-5) → methyl 3-fluoro-4-(4-morpholino)benzoate (495405-04-4)

Guidance literature:

In dimethyl sulfoxide; at 95 ℃; for 20h;

DOI:10.1021/jm020248u

Reference yield:

3,4-Difluorobenzoic acid (455-86-7) → methyl 3-fluoro-4-(4-morpholino)benzoate (495405-04-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 0.25 h / 0 °C

1.2: 20 °C

2.1: dipotassium hydrogenphosphate / dimethyl sulfoxide / 8 h / Reflux

With dipotassium hydrogenphosphate; thionyl chloride; In dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2016.09.007

Reference yield: 100.0%

methyl 3-fluoro-4-(4-morpholino)benzoate (495405-04-4) → 3-fluoro-4-(4-morpholino)benzyl alcohol (495404-89-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm020248u

upstream raw materials:

morpholine

methyl 3,4-difluorobenzoate

3,4-Difluorobenzoic acid

Downstream raw materials:

3-fluoro-4-(4-morpholino)benzyl alcohol

3-fluoro-4-(4-morpholino)benzaldehyde

3-fluoro-4-(4-morpholino)benzaldehydeoxime

3-chloro-5-fluoro-4-(4-morpholino)-N-hydroxybenzenecarboximidoyl chloride

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