1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID
• CAS No.: 495414-64-7
• Molecular Formula: C11H19NO5
• Molecular Weight: 245.276
• Hs Code.: 2933399090
• Mol file: 495414-64-7.mol

Synonyms:4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid;

Chemical Property of 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID

Chemical Property:

• Boiling Point: 398.2±42.0 °C(Predicted)
• PKA: 3.77±0.20(Predicted)
• PSA: 87.07000
• Density: 1.275±0.06 g/cm3(Predicted)
• LogP: 0.77090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic Acid is used in preparation of Lactam Oxaazaspiro compounds.

Technology Process of 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID

There total 2 articles about 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate (495415-09-3) → 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid (495414-64-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 ℃; for 18h; Temperature;

Reference yield:

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate (495415-09-3) + 1-tert-butyl 4-methyl 4-(2-methoxyethoxy)piperidine-1,4-dicarboxylate (1192189-92-6) → 1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid (495414-64-7) + 1-(tert-butoxycarbonyl)-4-(2-methoxyethoxy)piperidine-4-carboxylic acid (1309763-41-4)

Guidance literature:

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate; 1-tert-butyl 4-methyl 4-(2-methoxyethoxy)piperidine-1,4-dicarboxylate; With lithium hydroxide monohydrate; water; In methanol; at 60 ℃; for 2h;

With sodium hydrogen sulfate; In methanol; water; at 20 ℃;

Reference yield: 86.0%

1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid (495414-64-7) + (3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-amine trifluoroacetate → N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]-naphthalen-3-yl)-4-hydroxypiperidine-4-carboxamide

Guidance literature:

1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-4-carboxylic acid; (3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-amine trifluoroacetate; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

upstream raw materials:

1-tert-butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate

1-tert-butyl 4-methyl 4-(2-methoxyethoxy)piperidine-1,4-dicarboxylate

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