1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)-
CAS No.:496048-89-6
Molecular Formula:C₁₇H₁₈N₄O₅S₂
Molecular Weight:422.486
Hs Code.:
Mol file:496048-89-6.mol

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)-

There total 9 articles about 1-Pyrrolidinecarboxylic acid, 2-[4-(2-amino-2-oxoethyl)-2-thiazolyl]-4-mercapto-, (4-nitrophenyl)methyl ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4S)-4-Acetylsulfanyl-2-(4-carbamoylmethyl-thiazol-2-yl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 496048-89-6
(2S,4S)-2-(4-carbamoylmethylthiazol-2-yl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: With sodium hydroxide; In methanol; cooling;
DOI:10.1016/S0223-5234(02)01397-1

Reference yield:

: 2-[(2S,4R)-4-Hydroxy-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-2-yl]-thiazole-4-carboxylic acid ethyl ester

: 496048-89-6
(2S,4S)-2-(4-carbamoylmethylthiazol-2-yl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 4.61 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 85 percent / dimethylformamide; toluene / 3 h / 70 °C

3: 79.9 percent / aq. NH₄OH / methanol / 20 °C

4: Et₃N / CH₂Cl₂ / 0 °C

5: dimethylformamide; toluene / 70 °C

6: aq. NaOH / methanol / cooling

With ammonium hydroxide; sodium hydroxide; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0223-5234(02)01397-1

Reference yield:

: (2S,4R)-4-Benzoyloxy-2-carbamoyl-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 496048-89-6
(2S,4S)-2-(4-carbamoylmethylthiazol-2-yl)-4-mercapto-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 9 steps

1: 94.7 percent / Lawesson's reagent / tetrahydrofuran / 2 h / Heating

2: 89.2 percent / ethanol / 20 h / 20 °C

3: KOH / methanol / 2 h / cooling

4: 4.61 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 85 percent / dimethylformamide; toluene / 3 h / 70 °C

6: 79.9 percent / aq. NH₄OH / methanol / 20 °C

7: Et₃N / CH₂Cl₂ / 0 °C

8: dimethylformamide; toluene / 70 °C

9: aq. NaOH / methanol / cooling

With Lawessons reagent; potassium hydroxide; ammonium hydroxide; sodium hydroxide; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0223-5234(02)01397-1