1-Piperidineacetic acid, 4-(4-methylphenoxy)-a-oxo-

Base Information

• Chemical Name: 1-Piperidineacetic acid, 4-(4-methylphenoxy)-a-oxo-
• CAS No.: 496055-13-1
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.293
• Mol file: 496055-13-1.mol

Synonyms:

Chemical Property of 1-Piperidineacetic acid, 4-(4-methylphenoxy)-a-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperidineacetic acid, 4-(4-methylphenoxy)-a-oxo-

There total 7 articles about 1-Piperidineacetic acid, 4-(4-methylphenoxy)-a-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid ethyl ester (496055-12-0) → oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid (496055-13-1)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2004.05.053

Reference yield:

4-Chloropyridine (626-61-9) → oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid (496055-13-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1-(4-pyridyl)pyridinium chloride hydrochloride / 6 h / 220 °C

2: diethyl ether / 48 h / 20 °C

3: NaBH₄ / ethanol

4: H₂ / Pd/C / methanol / 20 °C

5: TEA / CHCl₃ / 2 h / 10 °C

6: aq. KOH / ethanol / 2 h / 20 °C

With potassium hydroxide; sodium tetrahydroborate; TEA; hydrogen; 1-(4-pyridyl)pyridinium chloride hydrochloride; palladium on activated charcoal; In methanol; diethyl ether; ethanol; chloroform;

DOI:10.1016/j.bmcl.2004.05.053

Reference yield:

p-cresol (106-44-5) → oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid (496055-13-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1-(4-pyridyl)pyridinium chloride hydrochloride / 6 h / 220 °C

2: diethyl ether / 48 h / 20 °C

3: NaBH₄ / ethanol

4: H₂ / Pd/C / methanol / 20 °C

5: TEA / CHCl₃ / 2 h / 10 °C

6: aq. KOH / ethanol / 2 h / 20 °C

With potassium hydroxide; sodium tetrahydroborate; TEA; hydrogen; 1-(4-pyridyl)pyridinium chloride hydrochloride; palladium on activated charcoal; In methanol; diethyl ether; ethanol; chloroform;

DOI:10.1016/j.bmcl.2004.05.053

upstream raw materials:

oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid ethyl ester

4-Chloropyridine

p-cresol

4-p-tolyloxy-pyridine

Refernces

• 1、 Barta-Szalai, Gizella,Borza, Istvan,Bozo, Eva,Kiss, Csilla,Agai, Bela,Proszenyak, Agnes,Keseru, Gyoergy M.,Gere, Aniko,Kolok, Sandor,Galgoczy, Kornel,Horvath, Csilla,Farkas, Sandor,Domany, Gyoergy. "Oxamides as novel NR2B selective NMDA receptor antagonists". . p. 3953 - 3956. Retrieved 2007/10/03.