Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl-

Base Information

• Chemical Name: Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl-
• CAS No.: 67293-88-3
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 288.319
• European Community (EC) Number: 621-670-6
• DSSTox Substance ID: DTXSID00217656
• Nikkaji Number: J66.313A
• Wikidata: Q83094264
• Mol file: 67293-88-3.mol

Synonyms:Morphine-d3;67293-88-3;Deuteriomorphine;Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl-;BRN 0582173;(4R,4aR,7S,7aR,12bS)-3-(trideuteriomethyl)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;Morphine-D3;Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(methyl-d3)-, (5?,6?)-;Morphine-methyl-d3 (7CI);(5?,6?)-7,8-Didehydro-4,5-epoxy-17-(methyl-d3)morphinan-3,6-diol;Morphine-d3 (CRM);C17H16D3NO3;DTXSID00217656;C17-H16-D3-N-O3;Morphine-D3 0.1 mg/ml in Methanol;Morphine-D3 1.0 mg/ml in Methanol;LS-91775;Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-(methyl-d3)-, (5.alpha.,6.alpha.)-

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Chemical Property of Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl-

Chemical Property:

• Vapor Pressure: 7.06E-10mmHg at 25°C
• Melting Point: >240oC (dec.)
• Boiling Point: 476.2°C at 760 mmHg
• Flash Point: 11 °C
• PSA: 52.93000
• Density: 1.45g/cm³
• LogP: 1.13600
• Storage Temp.: −20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 288.15532371
• Heavy Atom Count: 21
• Complexity: 494

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 36/37-45-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
• Isomeric SMILES: [2H]C([2H])([2H])N1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O
• Description: Morphine-d3 (CRM) (Item No. 24514) is an analytical reference standard intended for use as an internal standard for the quantification of morphine (Item Nos. 15464 | ISO60147) by GC- or LC-MS. Morphine is categorized as an opioid. It is a natural phenanthrene commonly used for its analgesic properties but has a high potential for addiction. Morphine is regulated as a Schedule II compound in the United States. Morphine-d3 (CRM) (Item No. 24514) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
• Uses: Morphine-d3, is the labeled analogue of Morphine (M652290), the principal alkaloid of opium. This is a controlled substance (opiate). Analgesic (narcotic).

Technology Process of Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl-

There total 2 articles about Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-trideuteriomethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H25NO7 → [2H3]-morphine (67293-88-3)

Guidance literature:

With lithium aluminium deuteride; In tetrahydrofuran; at 85 ℃; for 2.5h; Temperature; Inert atmosphere; Reflux;

Reference yield:

→ N-Trideuteriomethyl-normorphin (67293-88-3)

Guidance literature:

O³,N-Diaethoxycarbonyl-normorphin, 1. LiAlD4, 2. wss. HCl, Na-K-tartrat;

DOI:10.1021/jm00339a005

Refernces

• 1、 -. "[2 H 3]-method for synthesis of morphine". Paragraph 0057. . Retrieved 2017/01/19.