2-(Benzyloxy)-5-nitropyridine

Base Information

• Chemical Name: 2-(Benzyloxy)-5-nitropyridine
• CAS No.: 75926-54-4
• Molecular Formula: C12H10N2O3
• Molecular Weight: 230.223
• Hs Code.: 2933399090
• NSC Number: 165277
• DSSTox Substance ID: DTXSID70304284
• Nikkaji Number: J1.936.535B
• Wikidata: Q82050113
• Mol file: 75926-54-4.mol

Synonyms:2-(benzyloxy)-5-nitropyridine;75926-54-4;5-nitro-2-phenylmethoxypyridine;2-benzyloxy-5-nitro-pyridine;NSC165277;2-benzyloxy-5-nitropyridine;SCHEMBL221576;2-(Benzyloxy)-5-nitropyriidne;DTXSID70304284;LDSNUJNCJUGMKS-UHFFFAOYSA-N;CCG-54484;MFCD04111374;AKOS025393954;5-Nitro-2-[(phenylmethyl)oxy]pyridine;NSC-165277;FT-0757688;4X-5009;SR-01000643576-1

Chemical Property of 2-(Benzyloxy)-5-nitropyridine

Chemical Property:

• Vapor Pressure: 1.18E-05mmHg at 25°C
• Boiling Point: 380.6°C at 760 mmHg
• Flash Point: 184°C
• PSA: 67.94000
• Density: 1.284g/cm³
• LogP: 3.09200
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 230.06914219
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

99%, ^*data from raw suppliers

2-(Benzyloxy)-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=NC=C(C=C2)[N+](=O)[O-]

Technology Process of 2-(Benzyloxy)-5-nitropyridine

There total 5 articles about 2-(Benzyloxy)-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-5-nitropyridine (4548-45-2) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-5-nitropyridine (75926-54-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h; Inert atmosphere; Cooling with ice;

DOI:10.1002/anie.201305555

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) → 2-(benzyloxy)-5-nitropyridine (75926-54-4)

Guidance literature:

With benzyl alcohol;

DOI:10.1021/ja01197a063

Reference yield:

potassium 5-nitropyridine-2-sulfonate + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzyloxy)-5-nitropyridine (75926-54-4)

Guidance literature:

With sodium hydride; at 23 ℃; for 20h;

DOI:10.1039/b305620a

upstream raw materials:

iodomethylbenzene

2-chloro-5-nitropyridine

benzyl alcohol

Downstream raw materials:

3-amino-6-(benzyloxy)pyridine

2-<6-(benzyloxy)-3-nitro-2-pyridyl>acetonitrile

pyrrolo<3,2-b>pyrid-5-one

5-(benzyloxy)pyrrolo<3,2-b>pyridine