7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
CAS No.:496864-15-4
Molecular Formula:C₁₇H₁₉N₃O
Molecular Weight:281.357
Hs Code.:
DSSTox Substance ID:DTXSID90394566
Wikidata:Q27074389
Pharos Ligand ID:F9LN7JYR1MP5
ChEMBL ID:CHEMBL306498
Mol file:496864-15-4.mol

Synonyms:496864-15-4;Aloisine;Aloisine RP106;Aloisine, RP106;RP106;7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;RP-106;IN1538;7-Butyl-6-(4-methoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine;7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine;D00SEC;SCHEMBL79714;6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 38;BDBM7364;CHEMBL306498;GTPL5923;CHEBI:92890;DTXSID90394566;HMS3229A16;HSCI1_000247;RP 106;AKOS030240698;CCG-206815;NCGC00408885-01;HY-112336;FT-0661525;BRD-K51276371-001-01-8;Q27074389;7-N-Butyl-6-(4-methoxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine

Suppliers and Price of 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AloisineRP106
10mg
$ 140.00

Medical Isotopes, Inc.
AloisineRP106
10 mg
$ 845.00

Cayman Chemical
Aloisine RP106 ≥98%
1mg
$ 29.00

Cayman Chemical
Aloisine RP106 ≥98%
10mg
$ 204.00

Cayman Chemical
Aloisine RP106 ≥98%
5mg
$ 136.00

Cayman Chemical
Aloisine RP106 ≥98%
25mg
$ 458.00

Biosynth Carbosynth
Aloisine RP106
10 mg
$ 300.00

Biosynth Carbosynth
Aloisine RP106
25 mg
$ 680.00

Biosynth Carbosynth
Aloisine RP106
2 mg
$ 100.00

Biosynth Carbosynth
Aloisine RP106
1 mg
$ 65.00

Total 8 raw suppliers

Chemical Property of 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Chemical Property:

Melting Point:182-184oC
PSA：61.80000
Density:1.155g/cm3
LogP:3.67310
Storage Temp.:2-8°C
Solubility.:DMSO: >10mg/mL
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:281.152812238
Heavy Atom Count:21
Complexity:317

Purity/Quality:

99% ^*data from raw suppliers

AloisineRP106 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)OC
Uses A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk1/cyclin B, Cdk5/p35, and GSK-3 ( IC50 =700nM 1.5 uM, and 920 nM, respectively).

Technology Process of 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

There total 2 articles about 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 874-90-8
4-methoxybenzonitrile

: 6303-75-9
2-pentylpyrazine

: 496864-15-4
Aloisine

Guidance literature:: 2-pentylpyrazine; With lithium diisopropyl amide; In tetrahydrofuran; at -40 ℃; for 0.5h;

4-methoxybenzonitrile; In tetrahydrofuran; at -40 - 20 ℃; Further stages.;
DOI:10.1021/jm020319p