Carbamic acid, [(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino] -2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-, 2-propenyl ester

Base Information

Chemical Name:Carbamic acid, [(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino] -2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-, 2-propenyl ester
CAS No.:496917-73-8
Molecular Formula:C29H31Cl2N5O5
Molecular Weight:600.502
Hs Code.:

Carbamic acid,
[(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino]
-2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-,
2-propenyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino] -2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-, 2-propenyl ester

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Technology Process of Carbamic acid, [(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino] -2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-, 2-propenyl ester

There total 7 articles about Carbamic acid, [(2S)-2-[[5-chloro-4-[2-[[[5-chloro-2-(2-propenyloxy)phenyl]methyl]amino] -2-oxoethyl]-3,4-dihydro-3-oxopyrazinyl]amino]-3-phenylpropyl]-, 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2-allyloxy-5-chloro-benzylamine

: 496917-65-8
{3-[1-(allyloxycarbonylamino-methyl)-2-phenyl-ethylamino]-6-chloro-2-oxo-2H-pyrazin-1-yl}-acetic acid

: 496917-73-8
((S)-2-{4-[(2-Allyloxy-5-chloro-benzylcarbamoyl)-methyl]-5-chloro-3-oxo-3,4-dihydro-pyrazin-2-ylamino}-3-phenyl-propyl)-carbamic acid allyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00216-8

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 496917-73-8
((S)-2-{4-[(2-Allyloxy-5-chloro-benzylcarbamoyl)-methyl]-5-chloro-3-oxo-3,4-dihydro-pyrazin-2-ylamino}-3-phenyl-propyl)-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: HN₃; Ph₃P; DEAD

1.2: 86 percent / HCl gas

2.1: 73 percent / Et₃N / ethanol / 100 °C / sealed tube

3.1: 94 percent / N-chlorosuccinimide / 1,2-dichloro-ethane / 80 °C

4.1: 80 percent / SnCl₂ / methanol

5.1: 95 percent / LiOH / tetrahydrofuran

6.1: 93 percent / EDC; HOAt / dimethylformamide

With lithium hydroxide; N-chloro-succinimide; 1-hydroxy-7-aza-benzotriazole; tris-(2-chloro-ethyl)-amine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; tin(ll) chloride; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)00216-8

Reference yield:

: 450416-15-6
[3-(1-azidomethyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid ethyl ester

: 496917-73-8
((S)-2-{4-[(2-Allyloxy-5-chloro-benzylcarbamoyl)-methyl]-5-chloro-3-oxo-3,4-dihydro-pyrazin-2-ylamino}-3-phenyl-propyl)-carbamic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / N-chlorosuccinimide / 1,2-dichloro-ethane / 80 °C

2: 80 percent / SnCl₂ / methanol

3: 95 percent / LiOH / tetrahydrofuran

4: 93 percent / EDC; HOAt / dimethylformamide

With lithium hydroxide; N-chloro-succinimide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; tin(ll) chloride; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00216-8