Formamide, N-[2-(azidomethyl)phenyl]-

Base Information

• Chemical Name: Formamide, N-[2-(azidomethyl)phenyl]-
• CAS No.: 496963-66-7
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.178
• Mol file: 496963-66-7.mol

Synonyms:

Chemical Property of Formamide, N-[2-(azidomethyl)phenyl]-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: Methacryloyl oxyethyl dimethylbenzyl ammonium chloride, a quaternary ammonium compound, serves various purposes in different fields. In the realm of polymer chemistry, it plays a crucial role as a monomer in the synthesis of cationic polymers. These polymers are widely utilized in water treatment processes, serving as flocculants and coagulants to remove impurities and contaminants from water sources. In the cosmetics and personal care industry, this compound can be found in hair care products like conditioners and shampoos, where it acts as an antistatic agent and aids in detangling hair. Additionally, it has applications in the textile industry for imparting antimicrobial properties to fabrics. Its versatility in polymer science, water treatment, and personal care underscores its importance in these diverse fields, contributing to improved products and processes.

Technology Process of Formamide, N-[2-(azidomethyl)phenyl]-

There total 4 articles about Formamide, N-[2-(azidomethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H11NO4S → N-[2-(azidomethyl)phenyl]formamide (496963-66-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1039/d0nj00479k

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → N-[2-(azidomethyl)phenyl]formamide (496963-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/d0nj00479k

Reference yield:

N-[2-(hydroxymethyl)phenyl]formamide (104292-17-3) → N-[2-(azidomethyl)phenyl]formamide (496963-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/d0nj00479k

upstream raw materials:

N-[2-(chloromethyl)phenyl]formamide

N-[2-(hydroxymethyl)phenyl]formamide

2-Aminobenzyl alcohol

Downstream raw materials:

1-(azidomethyl)-2-isocyanobenzene

quinazoline

methyl quinazoline-2-carboxylate

Refernces

• 1、 Begum, Noor Shahina,Mohammed Imran, Khan,Yogesh Kumar, Gujjenahalli Ramalingaiah. "Mn-mediated oxidative radical cyclization of 2-(azidomethyl)phenyl isocyanides with carbazate: access to quinazoline-2-carboxylates". supporting information. p. 7001 - 7006. Retrieved 2020/05/16.