Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester

Base Information

Chemical Name:Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester
CAS No.:497159-99-6
Molecular Formula:C26H30N4O8S
Molecular Weight:558.612
Hs Code.:

Propanedioic acid,
[[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl
phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester

Synonyms:

Suppliers and Price of Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester

There total 6 articles about Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 304873-96-9
(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

: 497159-98-5
dimethyl 2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate

: 497159-99-6
dimethyl 2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)-2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate

Guidance literature:: dimethyl 2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.25h;

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1021/jm034141y

Reference yield:

: 3251-69-2
imidazole-4-acetic acid hydrochloride

: 497159-99-6
dimethyl 2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)-2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl / 16 h / 0 °C

2.1: 7 g / triethylamine / CH₂Cl₂ / 0.5 h

3.1: LHMDS / tetrahydrofuran / 0.5 h / 0 °C

3.2: 50 percent / tetrahydrofuran / 0 - 20 °C

4.1: sodium hydride / dimethylformamide / 1.25 h / 0 - 20 °C

4.2: 70 percent / dimethylformamide / 0.5 h / 0 °C

With hydrogenchloride; sodium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034141y

Reference yield:

: 51718-80-0
methyl 2-(1H-imidazol-4-yl)acetate hydrochloride

: 497159-99-6
dimethyl 2-({6-[(tert-butoxycarbonyl)amino]pyridin-3-yl}methyl)-2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 7 g / triethylamine / CH₂Cl₂ / 0.5 h

2.1: LHMDS / tetrahydrofuran / 0.5 h / 0 °C

2.2: 50 percent / tetrahydrofuran / 0 - 20 °C

3.1: sodium hydride / dimethylformamide / 1.25 h / 0 - 20 °C

3.2: 70 percent / dimethylformamide / 0.5 h / 0 °C

With sodium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034141y