2-Heptenedioic acid, 4-[[(2E)-1,4-dioxo-4-phenyl-2-butenyl](phenylmethyl)amino]-, 1-ethyl 7-(phenylmethyl) ester, (2E,4S)-

Base Information

Chemical Name:2-Heptenedioic acid, 4-[[(2E)-1,4-dioxo-4-phenyl-2-butenyl](phenylmethyl)amino]-, 1-ethyl 7-(phenylmethyl) ester, (2E,4S)-
CAS No.:497830-92-9
Molecular Formula:C33H33NO6
Molecular Weight:539.628
Hs Code.:

Synonyms:

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Chemical Property of 2-Heptenedioic acid, 4-[[(2E)-1,4-dioxo-4-phenyl-2-butenyl](phenylmethyl)amino]-, 1-ethyl 7-(phenylmethyl) ester, (2E,4S)-

Chemical Property:

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Technology Process of 2-Heptenedioic acid, 4-[[(2E)-1,4-dioxo-4-phenyl-2-butenyl](phenylmethyl)amino]-, 1-ethyl 7-(phenylmethyl) ester, (2E,4S)-

There total 6 articles about 2-Heptenedioic acid, 4-[[(2E)-1,4-dioxo-4-phenyl-2-butenyl](phenylmethyl)amino]-, 1-ethyl 7-(phenylmethyl) ester, (2E,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 497830-92-9
(E)-(S)-4-[Benzyl-((E)-4-oxo-4-phenyl-but-2-enoyl)-amino]-hept-2-enedioic acid 7-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

3: potassium tert-butylate / tetrahydrofuran

4: trifluoroacetic acid / 20 °C

5: CsCO₃ / dichloromethane

6: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 0 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)01711-2

Reference yield:

: 79069-53-7
Boc-L-Glu(OBzl)-al

: 497830-92-9
(E)-(S)-4-[Benzyl-((E)-4-oxo-4-phenyl-but-2-enoyl)-amino]-hept-2-enedioic acid 7-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran

2: trifluoroacetic acid / 20 °C

3: CsCO₃ / dichloromethane

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 0 °C

With 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)01711-2

Reference yield:

: (E)-(S)-4-Amino-hept-2-enedioic acid 7-benzyl ester 1-ethyl ester

: 497830-92-9
(E)-(S)-4-[Benzyl-((E)-4-oxo-4-phenyl-but-2-enoyl)-amino]-hept-2-enedioic acid 7-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CsCO₃ / dichloromethane

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 0 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0040-4039(02)01711-2