1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]-

Base Information

Chemical Name:1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]-
CAS No.:497850-36-9
Molecular Formula:C38H47N5O3S
Molecular Weight:653.889
Hs Code.:

1H-1-Benzazepine-4-carboxamide,
7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1,
2,4-triazol-3-yl)methyl]thio]phenyl]-

Synonyms:

Suppliers and Price of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]-

There total 7 articles about 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-propyl-N-[4-[[(4-propyl-4H-1, 2,4-triazol-3-yl)methyl]thio]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride

: 313738-96-4
7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 497850-36-9
7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1.5h;

S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride; With sodium hydroxide; more than 3 stages;

Reference yield:

: 3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride

: 7-[4-(2-butoxy-ethoxy)-phenyl]-1-propyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 497850-36-9
7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-[4-(2-butoxy-ethoxy)-phenyl]-1-propyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

3-(chloromethyl)-4-propyl-1H-1,2,4-triazole hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 497855-00-2
(4-propyl-4H-1,2,4-triazol-3-yl)methanol

: 497850-36-9
7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-N-({4-[(4-propyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 34 percent / SOCl₂ / Heating

2.1: Et₃N / tetrahydrofuran / 0 - 20 °C

2.2: NaOH / methanol; tetrahydrofuran / 20 °C

2.3: methanol; tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.10.021