1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2- methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]-

Base Information

Chemical Name:1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2- methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]-
CAS No.:497853-07-3
Molecular Formula:C41H52N4O3S
Molecular Weight:680.955
Hs Code.:

1H-1-Benzazepine-4-carboxamide,
7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2-
methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]-

Synonyms:

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Chemical Property of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2- methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]-

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Technology Process of 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2- methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]-

There total 6 articles about 1H-1-Benzazepine-4-carboxamide, 7-[4-(2-butoxyethoxy)phenyl]-2,3-dihydro-1-(2-methylpropyl)-N-[4-[[[1-(2- methylpropyl)-1H-imidazol-2-yl]methyl]thio]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(chloromethyl)-1-isobutyl-1H-imidazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 313736-34-4
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid

: 497853-07-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-isobutyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

2-(chloromethyl)-1-isobutyl-1H-imidazole hydrochloride; With sodium hydroxide; more than 3 stages;

Reference yield:

: 2-(chloromethyl)-1-isobutyl-1H-imidazole hydrochloride

: 130219-46-4
S-<(benzyloxy)carbonyl>-4-aminobenzenethiol

: 597583-16-9
7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride

: 497853-07-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-isobutyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: S-<(benzyloxy)carbonyl>-4-aminobenzenethiol; 7-[4-(2-butoxy-ethoxy)-phenyl]-1-isobutyl-2,3-dihydro-1H-benzo[b]azepine-4-carbonyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

2-(chloromethyl)-1-isobutyl-1H-imidazole hydrochloride; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmc.2004.10.021

Reference yield:

: 497855-76-2
1-isobutyl-1H-imidazole-2-carbaldehyde

: 497853-07-3
7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-isobutyl-1H-imidazol-2-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / LiAlH₄ / tetrahydrofuran / cooling

2.1: 67 percent / SOCl₂ / Heating

3.1: Et₃N / tetrahydrofuran / 0 - 20 °C

3.2: NaOH / methanol; tetrahydrofuran / 20 °C

3.3: methanol; tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.10.021