Propanoic acid, 3-amino-2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl )-1(2H)-pyrimidinyl]-4-fluorophenoxy]-3-oxo-, methyl ester

Base Information

• Chemical Name: Propanoic acid, 3-amino-2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl )-1(2H)-pyrimidinyl]-4-fluorophenoxy]-3-oxo-, methyl ester
• CAS No.: 497866-13-4
• Molecular Formula: C16H12ClF4N3O6
• Molecular Weight: 453.734
• Mol file: 497866-13-4.mol

Synonyms:

Chemical Property of Propanoic acid, 3-amino-2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl )-1(2H)-pyrimidinyl]-4-fluorophenoxy]-3-oxo-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 3-amino-2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl )-1(2H)-pyrimidinyl]-4-fluorophenoxy]-3-oxo-, methyl ester

There total 2 articles about Propanoic acid, 3-amino-2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl )-1(2H)-pyrimidinyl]-4-fluorophenoxy]-3-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl [2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]malonate (497866-11-2) → methyl 2-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-carboxyamideacetate (497866-13-4)

Guidance literature:

With ammonia; In methanol; chloroform; at 0 - 20 ℃; for 7h;

Reference yield:

2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenol (114136-60-6) + methyl 2-chloro-2-carboxamideacetate (497086-09-6) → methyl 2-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-carboxyamideacetate (497866-13-4)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 - 60 ℃; for 2.5h;

Reference yield:

methyl 2-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-carboxyamideacetate (497866-13-4) + acrolein (107-02-8,25068-14-8) → 3-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-3-methoxycarbonyl-3,4-dihydro-1H-pyridin-2-one (497866-15-6)

Guidance literature:

methyl 2-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-2-carboxyamideacetate; acrolein; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With toluene-4-sulfonic acid; In tetrahydrofuran; for 1h; Heating / reflux;

upstream raw materials:

dimethyl [2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]malonate

2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenol

methyl 2-chloro-2-carboxamideacetate

Downstream raw materials:

3-[2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-trifluoromethyl-1,2,3,6-tetrahydropyrimidin-1-yl)phenoxy]-3-methoxycarbonyl-3,4-dihydro-1H-pyridin-2-one