1-Fluoro-2,6-dichloropyridinium triflate

Base Information

• Chemical Name: 1-Fluoro-2,6-dichloropyridinium triflate
• CAS No.: 130433-68-0
• Molecular Formula: CF₃O₃S*C₅H₃Cl₂FN
• Molecular Weight: 316.06
• Hs Code.: 29333999
• European Community (EC) Number: 670-589-2
• DSSTox Substance ID: DTXSID60371980
• Mol file: 130433-68-0.mol

Synonyms:2,6-dichloro-1-fluoro-pyridine;

Chemical Property of 1-Fluoro-2,6-dichloropyridinium triflate

Chemical Property:

• Appearance/Colour: yellow powder
• Melting Point: 176-182 °C
• Boiling Point: 100oC at 760mmHg
• Flash Point: 15oC
• PSA: 69.46000
• Density: 1.46g/cm3
• LogP: 3.14570
• Storage Temp.: Refrigerator
• Sensitive.: air sensitive, moisture sensitiv
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 0
• Exact Mass: 314.9146822
• Heavy Atom Count: 17
• Complexity: 236

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-1-fluoropyridiniumTrifluoromethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; C
• Hazard Codes: C,Xi
• Statements: 34-35
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=[N+](C(=C1)Cl)F)Cl.C(F)(F)(F)S(=O)(=O)[O-]
• Uses: 2,6-Dichloro-1-fluoropyridinium triflate can be used in the fluorination of various organic compounds. Used in the fluorination of various organic compoundsFluoropyridinium triflates are versatile reagents for transformation of thioglycosides into ο-glycoside, glycosyl azide and sulfoxideElectrolytic partial fluorination and diastereoselective anodic fluorinationRegioselective, electrochemical fluorinationFluorination of alkenes with N-F type of reagents

Technology Process of 1-Fluoro-2,6-dichloropyridinium triflate

There total 2 articles about 1-Fluoro-2,6-dichloropyridinium triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2,6-dichloropyridine (2402-78-0) + trifluorormethanesulfonic acid (1493-13-6) → 1-fluoro-2,6-dichloropyridinium triflate (130433-68-0)

Guidance literature:

With fluorine; In various solvent(s); at -78 ℃; for 3h;

DOI:10.1246/bcsj.64.1081

Reference yield:

→ 1-fluoro-2,6-dichloropyridinium triflate (130433-68-0)

Guidance literature:

Reference yield: 35.0%

1-fluoro-2,6-dichloropyridinium triflate (130433-68-0) → 2,6-dichloro-4-hydroxypyridine (17228-74-9) + N-Fluoro-6-chloro-2-pyridone (135183-03-8)

Guidance literature:

With water; for 6h; Ambient temperature;

DOI:10.1246/bcsj.64.1081

upstream raw materials:

2,6-dichloropyridine

trifluorormethanesulfonic acid

Downstream raw materials:

2,6-dichloro-4-hydroxypyridine

N-Fluoro-6-chloro-2-pyridone