1,5-Naphthyridine-2-carboxylic acid

Base Information

• Chemical Name: 1,5-Naphthyridine-2-carboxylic acid
• CAS No.: 49850-62-6
• Molecular Formula: C9H6N2O2
• Molecular Weight: 174.16
• Hs Code.: 2933990090
• European Community (EC) Number: 672-888-3
• DSSTox Substance ID: DTXSID60497750
• Mol file: 49850-62-6.mol

Synonyms:1,5-Naphthyridine-2-carboxylic acid;49850-62-6;1,5-NAPHTHYRIDINE-2-CARBOXYLICACID;[1,5]Naphthyridine-2-carboxylic acid;SCHEMBL841536;DTXSID60497750;XCFUFRWRMISKRZ-UHFFFAOYSA-N;AMY34555;ZBA85062;MFCD06801138;AKOS006344718;PB30868;PS-3285;CS-0006527;FT-0677427;EN300-332150;P10420;[1,5]Naphthyridine-2-carboxylic acid, AldrichCPR;(S)-3-Amino-3-(2-trifluoromethyl-phenyl)-propionicacid;F1957-0374

Chemical Property of 1,5-Naphthyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 5.03E-06mmHg at 25°C
• Melting Point: >200°C
• Refractive Index: 1.697
• Boiling Point: 366.766 °C at 760 mmHg
• PKA: 3.22±0.30(Predicted)
• Flash Point: 175.614 °C
• PSA: 63.08000
• Density: 1.421 g/cm³
• LogP: 1.32800
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 174.042927438
• Heavy Atom Count: 13
• Complexity: 208

Purity/Quality:

97% ^*data from raw suppliers

1,5-naphthyridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=N2)C(=O)O)N=C1

Technology Process of 1,5-Naphthyridine-2-carboxylic acid

There total 7 articles about 1,5-Naphthyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

[1,5]naphthyridine-2-carboxylic acid ethyl ester (24677-83-6) → 1,5-naphthyridine-2-carboxylic acid (49850-62-6)

Guidance literature:

[1,5]naphthyridine-2-carboxylic acid ethyl ester; With sodium hydroxide; In methanol; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In methanol; water; pH=3 - 4;

Reference yield:

1,5-naphthyridine-2-carbonitrile (1142927-36-3) → 1,5-naphthyridine-2-carboxylic acid (49850-62-6)

Guidance literature:

With sulfuric acid; In water; at 100 ℃; for 15h;

DOI:10.1002/adsc.201901103

Reference yield:

ethyl 4,6-dichloro-1,5-naphthyridinecarboxylate (250674-50-1) → 1,5-naphthyridine-2-carboxylic acid (49850-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(PPh₃)4; sodium formate / dimethylsulfoxide / 100 °C

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium formate; In tetrahydrofuran; dimethyl sulfoxide; 1: Reduction / 2: Hydrolysis;

DOI:10.1016/S0960-894X(99)00435-7

upstream raw materials:

[1,5]naphthyridine-2-carboxylic acid ethyl ester

ethyl 4,6-dichloro-1,5-naphthyridinecarboxylate

1,5-naphthyridine

1,5-naphthyridine-2-carbonitrile

Downstream raw materials:

N-(5-phenylpentyl)-[1,5]naphthyridine-2-carboxamide

N-(4-phenoxy-2-butynyl)-[1,5]naphthyridine-2-carboxamide

N-(4-phenoxy-2-butenyl)-[1,5]naphthyridine-2-carboxamide

C₁₆H₁₃N₃O₂