(2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine

Base Information

Chemical Name:(2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine
CAS No.:5557-41-5
Molecular Formula:C18H18N2O2
Molecular Weight:294.3477
Hs Code.:
DSSTox Substance ID:DTXSID50970906
Wikidata:Q82954223
ChEMBL ID:CHEMBL1606139

Synonyms:n-(2,5-dimethoxyphenyl)-4-methylquinolin-2-amine;5557-41-5;(2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine;Oprea1_599747;Oprea1_604723;MLS001211222;CHEMBL1606139;DTXSID50970906;HMS2829O23;AKOS000631432;SMR000514340;AG-690/36933054;N-(2,5-dimethoxyphenyl)-4-methyl-2-quinolinamine

Suppliers and Price of (2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine

Chemical Property:

Vapor Pressure:4.42E-08mmHg at 25°C
Boiling Point:444°C at 760 mmHg
Flash Point:222.3°C
Density:1.191g/cm³
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:294.136827821
Heavy Atom Count:22
Complexity:352

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=NC2=CC=CC=C12)NC3=C(C=CC(=C3)OC)OC

Technology Process of (2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine

There total 12 articles about (2,5-Dimethoxy-phenyl)-(4-methyl-quinolin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (+)-deacetylpyrfolidine

: 5557-41-5
(-)-pyrifolidine

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1021/acs.orglett.7b01292

Reference yield:

: (2S,3aR,4R,7R,7aS)-di-tert-butyl 5-bromo-7-ethyl-8-oxo-2,3,3a,4,7,7a-hexahydro-1H-4,7-(epoxymethano)indole-1,2-dicarboxylate

: 5557-41-5
(-)-pyrifolidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic acid / neat (no solvent) / 5 h / 20 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 15 h / 20 °C

3.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 2 h / 20 °C / Inert atmosphere; Irradiation

3.2: 0.5 h / Inert atmosphere

4.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -40 °C

4.2: 4 h / Reflux

5.1: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / -78 °C / Reflux

7.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

8.1: benzene / 3 h / Reflux

8.2: Reflux

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / -78 - 45 °C

10.1: pyridine / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene; 4.2: |Wittig Olefination / 8.2: |Fischer Indole Synthesis;
DOI:10.1021/acs.orglett.7b01292

Reference yield:

: 1263381-01-6
3-ethyl-5-bromo-2-pyrone

: 5557-41-5
(-)-pyrifolidine

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene / 60 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / neat (no solvent) / 5 h / 20 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 15 h / 20 °C

4.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 2 h / 20 °C / Inert atmosphere; Irradiation

4.2: 0.5 h / Inert atmosphere

5.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -40 °C

5.2: 4 h / Reflux

6.1: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / -78 °C / Reflux

8.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C

9.1: benzene / 3 h / Reflux

9.2: Reflux

10.1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / -78 - 45 °C

11.1: pyridine / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; palladium 10% on activated carbon; hydrogen; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene; 5.2: |Wittig Olefination / 9.2: |Fischer Indole Synthesis;
DOI:10.1021/acs.orglett.7b01292