N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

Base Information

Chemical Name:N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide
CAS No.:499777-84-3
Molecular Formula:C20H22FN3O3S
Molecular Weight:403.477
Hs Code.:
European Community (EC) Number:946-492-9
DSSTox Substance ID:DTXSID301122484

Synonyms:499777-84-3;N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide;SCHEMBL4405833;KZVFRDBKQZRUIB-UHFFFAOYSA-N;DTXSID301122484;N-(1,1-Dimethylethyl)-4-[5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide;Benzenesulfonamide, N-(1,1-dimethylethyl)-4-[5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]-

Suppliers and Price of N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:403.13659091
Heavy Atom Count:28
Complexity:611

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)NS(=O)(=O)C1=CC=C(C=C1)N2C=NC=C2C3=CC(=C(C=C3)OC)F

Technology Process of N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide

There total 4 articles about N-tert-butyl-4-[5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: N-(3-fluoro-4-methoxybenzylidene)-4-(tert-butylaminosulfonyl)aniline

: 499777-84-3
1-(tert-butylaminosulfonylphenyl)-5-(3-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: With potassium carbonate; In methanol; 1,2-dimethoxyethane; for 3h; Heating;
DOI:10.1021/jm030765s

Reference yield:

: 209917-48-6
4-amino-N-(dimethylethyl)benzenesulfonamide

: 499777-84-3
1-(tert-butylaminosulfonylphenyl)-5-(3-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / toluene / 24 h / 110 °C

2: 87 percent / K₂CO₃ / methanol; 1,2-dimethoxy-ethane / 3 h / Heating

With potassium carbonate; In methanol; 1,2-dimethoxyethane; toluene;
DOI:10.1021/jm030765s

Reference yield:

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 499777-84-3
1-(tert-butylaminosulfonylphenyl)-5-(3-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 1,2-dimethoxy-ethane / 5 h / Heating

2: 89 percent / aq. KOH / methanol / 4 h / 100 °C

3: 100 percent / toluene / 24 h / 110 °C

4: 87 percent / K₂CO₃ / methanol; 1,2-dimethoxy-ethane / 3 h / Heating

With potassium hydroxide; potassium carbonate; In methanol; 1,2-dimethoxyethane; toluene;
DOI:10.1021/jm030765s