(+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride

Base Information

Chemical Name:(+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride
CAS No.:70470-07-4
Molecular Formula:C10H16ClNO
Molecular Weight:201.6931
Hs Code.:
NSC Number:296942

Synonyms:(+-)-Anatoxin A hydrochloride;70470-07-4;(+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride;Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, hydrochloride, (+-)-;(+)-ANATOXIN A HYDROCHLORIDE;NSC296942;NSC-296942;LS-67146

Suppliers and Price of (+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Boiling Point:291°C at 760 mmHg
Flash Point:124.7°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:201.0920418
Heavy Atom Count:13
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CCCC2CCC1N2.Cl

Technology Process of (+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride

There total 27 articles about (+-)-1-(9-Azabicyclo(4.2.1)non-2-en-2-yl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 90741-53-0,90821-08-2,92998-50-0
t-butyl-1-(9-azabicyclo<4.2.1>-non-2-ene-2-yl)ethanone carbamate

: 64314-16-5,70470-07-4,92216-03-0
(+/-)-anatoxin-a

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 2h; Ambient temperature;

Reference yield: 86.0%

: 2-(2-methyl-[1,3]dioxolan-2-yl)-9-(toluene-4-sulfonyl)-9-azabicyclo[4.2.1]non-2-ene

: 64314-16-5,70470-07-4,92216-03-0
(+/-)-anatoxin-a

Guidance literature:: 2-(2-methyl-[1,3]dioxolan-2-yl)-9-(toluene-4-sulfonyl)-9-azabicyclo[4.2.1]non-2-ene; With magnesium; In methanol; at 20 ℃; for 1.16667h; Sonication;

With hydrogenchloride; In chloroform; for 0.00277778h;
DOI:10.1039/b804304c

Reference yield:

: 112009-92-4
ethyl 2-aminohepta-5,6-dienoate

: 64314-16-5,70470-07-4,92216-03-0
(+/-)-anatoxin-a

Guidance literature:: Multi-step reaction with 17 steps

1: CH₂Cl₂

2: 88 percent / AgBF₄ / CH₂Cl₂ / 72 h / Ambient temperature

3: CF₃CO₂H / CH₂Cl₂ / Ambient temperature

4: pyridine / 0 °C

5: 1) B₂H₆, 2) aq. NaOH, 30percent aq. H₂O₂ / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.

6: 63 percent / tetrahydrofuran / 0.17 h / -10 °C

7: 78 percent / PPh₃, 2 M Br₂ / tetrahydrofuran / a) 0 deg C, 10 min, b) up to room temp.

8: 83 percent / NaH / dimethylsulfoxide / 2 h / 40 °C

9: 92 percent / Al-Hg / tetrahydrofuran; H₂O / 3 h / 60 °C

10: 1) LDA / 1) DME, hexane, -78 deg C, 20 min, 2) DME, 5 min

11: NaH / tetrahydrofuran / 14 h / Ambient temperature

12: liquid ammonia, lithium / tetrahydrofuran / 0.17 h / -78 °C

13: methanol / 16 h

14: 1) PhSeCl, 2) MCPBA / 1) CH₂Cl₂, -30 deg C, 30 min, 2) CH₂Cl₂, -78 deg C, 10 min

15: diethyl ether / -78 deg C up to -40 deg C, 10 min

16: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 0.5 h / Ambient temperature

17: 98 percent / conc. HCl / ethyl acetate / 2 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; Phenylselenyl chloride; aluminium amalgam; ammonia; dihydrogen peroxide; bromine; sodium acetate; lithium; sodium hydride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; pyridinium chlorochromate; trifluoroacetic acid; diborane; lithium diisopropyl amide; silver tetrafluoroborate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;