6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

Base Information

Chemical Name:6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
CAS No.:103361-43-9
Molecular Formula:C9H10N2O2
Molecular Weight:178.19
Hs Code.:2934999090
European Community (EC) Number:849-801-4
DSSTox Substance ID:DTXSID70377458
Wikidata:Q82166682
Mol file:103361-43-9.mol

Synonyms:103361-43-9;6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one;6-Amino-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one;6-amino-4-methyl-1,4-benzoxazin-3-one;MFCD01834021;6-amino-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-3-one;2H-1,4-Benzoxazin-3(4H)-one,6-amino-4-methyl-;6-Amino-4-methyl-4H-benzo[1,4]oxazin-3-one;Oprea1_136513;SCHEMBL653919;DTXSID70377458;QXLKSGOSLHFMIU-UHFFFAOYSA-N;HMS1703K03;BBL029482;STK801784;AKOS000601822;SY192499;CS-0107307;FT-0677845;EN300-95793;W18825;8Y-0704;AK-198/11159068;J-518231;Z425638104;6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one, AldrichCPR

Suppliers and Price of 6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
50mg
$ 45.00

SynQuest Laboratories
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
10 g
$ 896.00

SynQuest Laboratories
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
1 g
$ 240.00

SynQuest Laboratories
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
5 g
$ 472.00

Sigma-Aldrich
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one Aldrich
1g
$ 99.60

Matrix Scientific
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
1g
$ 568.00

Matrix Scientific
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
500mg
$ 134.00

Matrix Scientific
6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one
5g
$ 1700.00

Crysdot
6-Amino-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 95+%
5g
$ 645.00

Chemenu
6-Amino-4-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 95%
5g
$ 609.00

Total 13 raw suppliers

Chemical Property of 6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

Chemical Property:

Vapor Pressure:1.32E-09mmHg at 25°C
Melting Point:152-153.5 °C
Refractive Index:1.618
Boiling Point:486.2 °C at 760 mmHg
PKA:3.96±0.20(Predicted)
Flash Point:247.9 °C
PSA：55.56000
Density:1.299 g/cm³
LogP:1.27020
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:178.074227566
Heavy Atom Count:13
Complexity:220

Purity/Quality:

98%min ^*data from raw suppliers

6-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 52

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)COC2=C1C=C(C=C2)N

Technology Process of 6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

There total 5 articles about 6-amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 103361-68-8
6-Nitro-4-methyl-2H-1,4-benzoxazin-3(4H)-one

: 103361-43-9
6-amino-4-methyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: With water; iron; In ethanol; at 60 ℃; for 18h;

Reference yield:

: 81721-87-1
6-nitro-4H-benzo[1,4]oxazin-3-one

: 103361-43-9
6-amino-4-methyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1a) DMF, RT, 15 min, 1b) 50 to 60 deg C, 2) DMF, 100 deg C, 4 h

2: 79 percent / hydrazine hydrate / Raney nickel / ethanol / 2 h / Heating

With sodium hydride; hydrazine hydrate; nickel; In ethanol;

Reference yield:

: 99-57-0
2-hydroxy-5-nitroaniline

: 103361-43-9
6-amino-4-methyl-4H-benzo[1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 2.67 h / 0 - 80 °C

2: potassium carbonate / acetone / 2 h / Reflux

3: iron; ammonium chloride / ethanol; water / 4 h / 80 - 85 °C

With N-benzyl-N,N,N-triethylammonium chloride; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; In ethanol; water; acetone; acetonitrile;