4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride

Base Information

Chemical Name:4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride
CAS No.:96719-66-3
Molecular Formula:C₂₂H₂₁NO₂*ClH
Molecular Weight:367.875
Hs Code.:
DSSTox Substance ID:DTXSID10914361

Synonyms:4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride;Phenol, 4-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)-, hydrochloride;96719-66-3;DTXSID10914361;LS-105141;4-(6-Methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)phenol--hydrogen chloride (1/1)

Suppliers and Price of 4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride

Chemical Property:

Vapor Pressure:9.69E-12mmHg at 25°C
Boiling Point:527.4°C at 760 mmHg
Flash Point:272.8°C
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:367.1339066
Heavy Atom Count:26
Complexity:414

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(N(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)O.Cl

Technology Process of 4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride

There total 7 articles about 4-(1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-isoquinolinyl)phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96719-65-2
1-(4-Benzyloxy-phenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinoline

: 96719-66-3
4-(6-Methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenol; hydrochloride

Guidance literature:: With hydrogenchloride; at 80 - 90 ℃; for 1h;

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 96719-66-3
4-(6-Methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenol; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / benzene / 1 h / Heating

2: diethyl ether / Ambient temperature

3: 74 percent / LAH / dioxane; diethyl ether

4: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

5: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

6: NaBH₄ / methanol

7: conc. HCl / 1 h / 80 - 90 °C

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether; benzene;

Reference yield:

: 51009-27-9
[2-(3-Methoxy-phenyl)-ethyl]-phenyl-amine

: 96719-66-3
4-(6-Methoxy-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

2: 1.) POCl₃, 2.) KI / 1.) reflux, 2.) H₂O

3: NaBH₄ / methanol

4: conc. HCl / 1 h / 80 - 90 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium iodide; trichlorophosphate; In methanol;