Dazepinil

Base Information

• Chemical Name: Dazepinil
• CAS No.: 75991-50-3
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 250.343
• Mol file: 75991-50-3.mol

Synonyms:Dazepinil

Chemical Property of Dazepinil

Chemical Property:

• PSA: 15.60000
• LogP: 3.33920

Purity/Quality:

DAZEPINIL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antidepressant.

Technology Process of Dazepinil

There total 9 articles about Dazepinil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-nitrophenyl)acetyl chloride (22751-23-1) → (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine (75241-19-9,75991-50-3,104931-88-6)

Guidance literature:

Multi-step reaction with 8 steps

2: 72 percent / sodium acetate, hydroxylamine hydrochloride / ethanol; H₂O / 1 h / Heating

3: 74 percent / pyridine / 0.75 h / Heating

4: 1.0 M borane in THF / 1.) 5 deg C, 30 min, 2.) RT, 48 h

5: 68 percent / 48 h / 80 °C

6: 1.0 M borane in THF / 4 h / Ambient temperature

7: Fe, concd. hydrochloric acid / aq. ethanol; H₂O / 0.5 h / Heating

8: glacial acetic acid / 2 h / Heating

With pyridine; hydrogenchloride; borane-THF; hydroxylamine hydrochloride; sodium acetate; iron; acetic acid; In ethanol; water;

DOI:10.1021/jm00346a003

Reference yield:

2-(2-nitrophenyl)-1-phenylethanone (4212-33-3) → (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine (75241-19-9,75991-50-3,104931-88-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 72 percent / sodium acetate, hydroxylamine hydrochloride / ethanol; H₂O / 1 h / Heating

2: 74 percent / pyridine / 0.75 h / Heating

3: 1.0 M borane in THF / 1.) 5 deg C, 30 min, 2.) RT, 48 h

4: 68 percent / 48 h / 80 °C

5: 1.0 M borane in THF / 4 h / Ambient temperature

6: Fe, concd. hydrochloric acid / aq. ethanol; H₂O / 0.5 h / Heating

7: glacial acetic acid / 2 h / Heating

With pyridine; hydrogenchloride; borane-THF; hydroxylamine hydrochloride; sodium acetate; iron; acetic acid; In ethanol; water;

DOI:10.1021/jm00346a003

Reference yield:

2-(2-nitrophenyl)-1-phenylethanone oxime (15582-92-0) → (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine (75241-19-9,75991-50-3,104931-88-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 74 percent / pyridine / 0.75 h / Heating

2: 1.0 M borane in THF / 1.) 5 deg C, 30 min, 2.) RT, 48 h

3: 68 percent / 48 h / 80 °C

4: 1.0 M borane in THF / 4 h / Ambient temperature

5: Fe, concd. hydrochloric acid / aq. ethanol; H₂O / 0.5 h / Heating

6: glacial acetic acid / 2 h / Heating

With pyridine; hydrogenchloride; borane-THF; iron; acetic acid; In ethanol; water;

DOI:10.1021/jm00346a003

upstream raw materials:

Triethyl orthoacetate

(+/-)-2-amino-N-methyl-α-phenylbenzenethanamine

(2-nitrophenyl)acetyl chloride

2-(2-nitrophenyl)-1-phenylethanone

Refernces