Glycine, N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl ]-D-seryl-, 2-propenyl ester

Base Information

Chemical Name:Glycine, N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl ]-D-seryl-, 2-propenyl ester
CAS No.:500734-31-6
Molecular Formula:C₅₂H₇₄Cl₂N₄O₁₂SSi
Molecular Weight:1078.24
Hs Code.:

Glycine,
N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon
yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct
yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl
]-D-seryl-, 2-propenyl ester

Synonyms:

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Chemical Property of Glycine, N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl ]-D-seryl-, 2-propenyl ester

Chemical Property:

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Technology Process of Glycine, N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl ]-D-seryl-, 2-propenyl ester

There total 18 articles about Glycine, N-[(2S)-2-[[(3S)-7,7-dichloro-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbon yl]amino]-2-methylpropyl]-4-thiazolyl]carbonyl]oxy]-2,2-dimethyl-1-oxooct yl]oxy]-3-hydroxy-3-methyl-1-oxobutyl]-O-[(1,1-dimethylethyl)diphenylsilyl ]-D-seryl-, 2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37526-89-9
benzyl 3-methylbut-2-enoate

: 500734-31-6
2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-thiazole-4-carboxylic acid 1-(1-{1-[1-(allyloxycarbonylmethyl-carbamoyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethylcarbamoyl]-2-hydroxy-2-methyl-propoxycarbonyl}-1-methyl-ethyl)-5,5-dichloro-hexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: AD-mix-β; MeSO2NH2 / H2O; 2-methyl-propan-2-ol

2: H₂ / 5 percent Pd/C / tetrahydrofuran / 0.5 h / 20 °C / 760 Torr

3: 129 mg / KHCO₃ / dimethylformamide / 7 h / 20 °C

4: 66 percent / 2,4,6-trichlorobenzoyl chloride; triethylamine; DMAP / toluene / 12 h / 60 °C

5: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

6: 42 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 17 h / 20 °C

With morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonamide; diethyl cyanophosphonate; AD-mix-β; 2,4,6-trichlorobenzoyl chloride; hydrogen; potassium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 1: Sharpless reaction;
DOI:10.1016/S0040-4020(02)01224-3

Reference yield:

: 176505-53-6
benzyl (2S)-2,3-dihydroxy-3-methylbutanoate

: 500734-31-6
2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-thiazole-4-carboxylic acid 1-(1-{1-[1-(allyloxycarbonylmethyl-carbamoyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethylcarbamoyl]-2-hydroxy-2-methyl-propoxycarbonyl}-1-methyl-ethyl)-5,5-dichloro-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 5 percent Pd/C / tetrahydrofuran / 0.5 h / 20 °C / 760 Torr

2: 129 mg / KHCO₃ / dimethylformamide / 7 h / 20 °C

3: 66 percent / 2,4,6-trichlorobenzoyl chloride; triethylamine; DMAP / toluene / 12 h / 60 °C

4: morpholine; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

5: 42 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 17 h / 20 °C

With morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethyl cyanophosphonate; 2,4,6-trichlorobenzoyl chloride; hydrogen; potassium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(02)01224-3

Reference yield:

: 1028310-61-3
2-((S)-1-tert-Butoxycarbonylamino-2-methyl-propyl)-thiazole-4-carboxylic acid (S)-1-[1-((S)-1-carboxy-2-hydroxy-2-methyl-propoxycarbonyl)-1-methyl-ethyl]-5,5-dichloro-hexyl ester

: [2-amino-3-(tert-butyl-diphenyl-silanyloxy)-propionylamino]-acetic acid allyl ester; hydrochloride

: 500734-31-6
2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-thiazole-4-carboxylic acid 1-(1-{1-[1-(allyloxycarbonylmethyl-carbamoyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethylcarbamoyl]-2-hydroxy-2-methyl-propoxycarbonyl}-1-methyl-ethyl)-5,5-dichloro-hexyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1016/S0040-4020(02)01224-3