11-Oxa-2,6,9-triazatridecanoic acid, 2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl- 8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester, (4S,5S,8S)-

Base Information

Chemical Name:11-Oxa-2,6,9-triazatridecanoic acid, 2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl- 8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester, (4S,5S,8S)-
CAS No.:500767-30-6
Molecular Formula:C37H48N4O7
Molecular Weight:660.811
Hs Code.:

11-Oxa-2,6,9-triazatridecanoic acid,
2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl-
8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester,
(4S,5S,8S)-

Synonyms:

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Chemical Property of 11-Oxa-2,6,9-triazatridecanoic acid, 2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl- 8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester, (4S,5S,8S)-

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Technology Process of 11-Oxa-2,6,9-triazatridecanoic acid, 2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl- 8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester, (4S,5S,8S)-

There total 5 articles about 11-Oxa-2,6,9-triazatridecanoic acid, 2-[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-4-hydroxy-12,12-dimethyl- 8-(1-methylethyl)-7,10-dioxo-5-(phenylmethyl)-, phenylmethyl ester, (4S,5S,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: ((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-((R)-1-carbamoyl-2-phenyl-ethyl)-carbamic acid benzyl ester

: 500767-30-6
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020951i

Reference yield:

: 5241-58-7,5241-59-8,17193-31-6,60058-39-1
D-Phenylalaninamide

: 500767-30-6
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / propan-2-ol / Heating

2: 73 percent / aq. Na₂CO₃ / tetrahydrofuran / 20 °C

3: HCl / ethyl acetate / 20 °C

4: 0.43 g / TBTU; DIEA / dimethylformamide / 20 °C

With hydrogenchloride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 500767-30-6
(2R,5S,6S)-3-aza-2-benzyl-3-(benzyloxycarbonyl)-6-[[(tert-butyloxycarbonyl)-L-valinyl]amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / propan-2-ol / Heating

2: 73 percent / aq. Na₂CO₃ / tetrahydrofuran / 20 °C

3: HCl / ethyl acetate / 20 °C

4: 0.43 g / TBTU; DIEA / dimethylformamide / 20 °C

With hydrogenchloride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i