Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester

Base Information

Chemical Name:Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester
CAS No.:500770-32-1
Molecular Formula:C39H43O13P
Molecular Weight:750.736
Hs Code.:

Phosphoric acid,
6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4-
[[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl
diethyl ester

Synonyms:

Suppliers and Price of Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester

There total 14 articles about Phosphoric acid, 6,11-dihydro-5,7-dihydroxy-9-(methoxymethoxy)-8-methyl-6,11-dioxo-4- [[2-[2-(phenylmethoxy)propyl]-1,3-dioxolan-2-yl]methyl]-2-naphthacenyl diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 500770-23-0
3-benzenesulfonyl-5,7-bis-methoxymethoxy-6-methyl-3H-isobenzofuran-1-one

: 500770-24-1
phosphoric acid 4-[2-(2-benzyloxy-propyl)-[1,3]dioxolan-2-ylmethyl]-5-oxo-1,4,4a,5,8,8a-hexahydro-naphthalen-2-yl ester diethyl ester

: 500770-32-1
phosphoric acid 4-[2-(2-benzyloxy-propyl)-[1,3]dioxolan-2-ylmethyl]-5,7-dihydroxy-9-methoxymethoxy-8-methyl-6,11-dioxo-6,11-dihydro-naphthacen-2-yl ester diethyl ester

Guidance literature:: 3-benzenesulfonyl-5,7-bis-methoxymethoxy-6-methyl-3H-isobenzofuran-1-one; phosphoric acid 4-[2-(2-benzyloxy-propyl)-[1,3]dioxolan-2-ylmethyl]-5-oxo-1,4,4a,5,8,8a-hexahydro-naphthalen-2-yl ester diethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 60 ℃; for 2h;

With benzyl methyl ether; palladium on activated charcoal; In toluene; at 110 ℃; for 15h;
DOI:10.7164/antibiotics.55.1076

Reference yield:

: 608-25-3
2-methylbenzene-1,3-diol

: 500770-32-1
phosphoric acid 4-[2-(2-benzyloxy-propyl)-[1,3]dioxolan-2-ylmethyl]-5,7-dihydroxy-9-methoxymethoxy-8-methyl-6,11-dioxo-6,11-dihydro-naphthacen-2-yl ester diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 87 percent / NaH / dimethylformamide / 0.5 h / 0 - 20 °C

2.1: 78 percent / s-BuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C

3.1: 82 percent / s-BuLi; TMEDA / tetrahydrofuran / 0.5 h / -78 - 20 °C

4.1: AcOH / 16 h / 80 °C

4.2: i-Pr₂NEt / dimethylformamide / 0.5 h / -40 - 20 °C

5.1: LiN(TMS)2 / tetrahydrofuran / 2 h / -78 - 60 °C

5.2: 64 percent / BnOMe / Pd-C / toluene / 15 h / 110 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.55.1076

Reference yield:

: 221449-83-8
1,3-bis(methoxymethoxy)-2-methylbenzene

: 500770-32-1
phosphoric acid 4-[2-(2-benzyloxy-propyl)-[1,3]dioxolan-2-ylmethyl]-5,7-dihydroxy-9-methoxymethoxy-8-methyl-6,11-dioxo-6,11-dihydro-naphthacen-2-yl ester diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / s-BuLi / tetrahydrofuran / 0.5 h / -78 - 20 °C

2.1: 82 percent / s-BuLi; TMEDA / tetrahydrofuran / 0.5 h / -78 - 20 °C

3.1: AcOH / 16 h / 80 °C

3.2: i-Pr₂NEt / dimethylformamide / 0.5 h / -40 - 20 °C

4.1: LiN(TMS)2 / tetrahydrofuran / 2 h / -78 - 60 °C

4.2: 64 percent / BnOMe / Pd-C / toluene / 15 h / 110 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.7164/antibiotics.55.1076