Carbamic acid, [(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-( 7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-( 7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester
CAS No.:501034-12-4
Molecular Formula:C45H44N2O8
Molecular Weight:740.853
Hs Code.:

Carbamic acid,
[(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-(
7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-,
9H-fluoren-9-ylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-( 7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

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Technology Process of Carbamic acid, [(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-( 7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester

There total 5 articles about Carbamic acid, [(1S)-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-[[2-methoxy-5-[(1Z)-2-( 7-methoxy-1,3-benzodioxol-5-yl)ethenyl]phenyl]amino]-2-oxoethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 71989-38-3,118488-18-9,204384-67-8
Fmoc-Tyr(tBu)-OH

: 501033-98-3
2-Methoxy-5-[(Z)-2-(7-methoxy-benzo[1,3]dioxol-5-yl)-vinyl]-phenylamine

: 501034-12-4
3,4-methylenedioxy-5,4'-dimethoxy-3'-(O-Bu^t-N^α-Fmoc-L-Tyr)amido-Z-stilbene

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm020204l

Reference yield:

: 3,4-methylenedioxy-5-methoxybenzyltriphenylphosphonium bromide

: 501034-12-4
3,4-methylenedioxy-5,4'-dimethoxy-3'-(O-Bu^t-N^α-Fmoc-L-Tyr)amido-Z-stilbene

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / tetrahydrofuran / 4 h / 20 °C

1.2: 31 percent / tetrahydrofuran / 18 h

2.1: 77 percent / Zn; AcOH / 1.5 h

3.1: 91 percent / bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; DIPEA / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm020204l

Reference yield:

: 31680-08-7
4-methoxy-3-nitrobenzaldehyde

: 501034-12-4
3,4-methylenedioxy-5,4'-dimethoxy-3'-(O-Bu^t-N^α-Fmoc-L-Tyr)amido-Z-stilbene

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / tetrahydrofuran / 4 h / 20 °C

1.2: 31 percent / tetrahydrofuran / 18 h

2.1: 77 percent / Zn; AcOH / 1.5 h

3.1: 91 percent / bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; DIPEA / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm020204l