Methanone, [1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]-

Base Information

Chemical Name:Methanone, [1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]-
CAS No.:501660-44-2
Molecular Formula:C32H44ClN3O3Si2
Molecular Weight:610.344
Hs Code.:

Methanone,
[1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl
silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanone, [1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]-

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Technology Process of Methanone, [1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]-

There total 7 articles about Methanone, [1-[(4-chlorophenyl)methyl]-1H-indol-3-yl][4-[[[(1,1-dimethylethyl)dimethyl silyl]oxy]methyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 926622-90-4
[4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-[1-(4-chloro-benzyl)-1H-indol-3-yl]-methanol

: 501660-44-2
[4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-[1-(4-chloro-benzyl)-1H-indol-3-yl]-methanone

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.07.020

Reference yield:

: 501660-43-1
4-(((tert-butyldimethylsilyl)oxy)methyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole

: 501660-44-2
[4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-[1-(4-chloro-benzyl)-1H-indol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C

1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -78 °C

2.1: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene;
DOI:10.1016/j.bmcl.2006.07.020

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 501660-44-2
[4-(tert-butyl-dimethyl-silanyloxymethyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-[1-(4-chloro-benzyl)-1H-indol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / NaH / 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; heptane; ethylbenzene / 0.5 h / -78 °C

2.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -78 °C

3.1: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene;
DOI:10.1016/j.bmcl.2006.07.020