1-BOC-4-[(2-METHOXYPHENYL)AMINO]-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-[(2-METHOXYPHENYL)AMINO]-PIPERIDINE
• CAS No.: 501673-75-2
• Molecular Formula: C17H26N2O3
• Molecular Weight: 306.405
• Mol file: 501673-75-2.mol

Synonyms:4-(o-anisidino)-1-(tert-butoxycarbonyl)piperidine;4-(2-methoxyphenylamino)-piperidine-1-carboxylic acid tert-butyl ester;4-(2-methoxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 1-BOC-4-[(2-METHOXYPHENYL)AMINO]-PIPERIDINE

Chemical Property:

• PSA: 50.80000
• LogP: 3.51750

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-((2-methoxyphenyl)amino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-4-[(2-METHOXYPHENYL)AMINO]-PIPERIDINE

There total 6 articles about 1-BOC-4-[(2-METHOXYPHENYL)AMINO]-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-bromoanisole (578-57-4) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 1-tert-butoxycarbonyl-4-[(2-methoxyphenyl)amino]piperidine (501673-75-2)

Guidance literature:

With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In xylene; at 130 ℃; for 24h;

DOI:10.1021/jo062301i

Reference yield: 36.0%

→ 1-tert-butoxycarbonyl-4-[(2-methoxyphenyl)amino]piperidine (501673-75-2)

Guidance literature:

Reference yield: 35.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-methoxy-phenylamine (90-04-0) → 1-tert-butoxycarbonyl-4-[(2-methoxyphenyl)amino]piperidine (501673-75-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 6h;

upstream raw materials:

2-bromoanisole

1-(tert-butoxycarbonyl)-4-aminopiperidine

N-phenylmethylidenepiperidinyl-4-amine

4-(benzylidene-amino)-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-(tert-Butoxycarbonyl)-4-[N-(2-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

4-N-(2-methoxyphenyl)aminopiperidine

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