1-BOC-4-[(4-METHYLPHENYL)AMINO]-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-[(4-METHYLPHENYL)AMINO]-PIPERIDINE
• CAS No.: 501673-99-0
• Molecular Formula: C17H26N2O2
• Molecular Weight: 290.406
• Mol file: 501673-99-0.mol

Synonyms:tert-Butyl 4-(p-toluidino)piperidin-1-carboxylate;4-p-tolylamino-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-4-[(4-methylphenyl)amino]-piperidine;1-(tert-butoxycarbonyl)-4-[(4-methylphenyl)amino]piperidine;

Chemical Property of 1-BOC-4-[(4-METHYLPHENYL)AMINO]-PIPERIDINE

Chemical Property:

• PSA: 41.57000
• LogP: 3.81730

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-p-Tolylamino-piperidine-1-carboxylic acid tert-butyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-4-[(4-METHYLPHENYL)AMINO]-PIPERIDINE

There total 3 articles about 1-BOC-4-[(4-METHYLPHENYL)AMINO]-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 1-(tert-Butoxycarbonyl)-4-[(4-methylphenyl)amino]piperidine (501673-99-0)

Guidance literature:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + p-toluidine (106-49-0,12221-03-3) → 1-(tert-Butoxycarbonyl)-4-[(4-methylphenyl)amino]piperidine (501673-99-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; for 48h;

Reference yield:

4-methylphenylboronic acid (5720-05-8) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 1-(tert-Butoxycarbonyl)-4-[(4-methylphenyl)amino]piperidine (501673-99-0)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; for 41h; Reflux;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

p-toluidine

4-methylphenylboronic acid

1-(tert-butoxycarbonyl)-4-aminopiperidine

Downstream raw materials:

4-(p-toluidino)piperidine

tert-butyl 4-[bis(4-methylphenyl)amino]piperidine-1-carboxylate

C₁₉H₂₄N₂

(2R)-1-{4-[bis(4-methylphenyl)amino]piperidin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol

Refernces

• 1、 -. "Novel derivatives of indole and pyrrole, method for the production thereof and pharmaceutical compositions containing same". Paragraph 0336; 0337; 0338. . Retrieved 2016/10/09.
• 2、 -. "Cyclic amine compounds and pharmaceutical composition containing the same". . . Retrieved 2008/06/13.