N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline

Base Information

• Chemical Name: N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline
• CAS No.: 502846-06-2
• Molecular Formula: C14H15N3
• Molecular Weight: 225.293
• DSSTox Substance ID: DTXSID60282845
• ChEMBL ID: CHEMBL1719488
• Mol file: 502846-06-2.mol

Synonyms:MLS002639231;N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline;HMS3079H13;CHEMBL1719488;DTXSID60282845;SMR001548678

Chemical Property of N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 225.126597491
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)C=CC2=NC=CN=C2

Technology Process of N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline

There total 1 articles about N,N-dimethyl-4-(2-pyrazin-2-ylethenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-Methylpyrazine (109-08-0) + 4-dimethylamino-benzaldehyde (100-10-7) → (E)-N,N-dimethyl-4-(2-(pyrazin-2-yl)vinyl)aniline (502846-06-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 15h;

DOI:10.1002/ejoc.201601204

Reference yield: 94.0%

4-bromo-N,N-dimethylaniline (586-77-6) + (E)-N,N-dimethyl-4-(2-(pyrazin-2-yl)vinyl)aniline (502846-06-2) → 4,4′-(2-(pyrazin-2-yl)ethene-1,1-diyl)bis(N,N-dimethylaniline)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.7b03024

Reference yield: 94.0%

bromobenzene (108-86-1,52753-63-6) + (E)-N,N-dimethyl-4-(2-(pyrazin-2-yl)vinyl)aniline (502846-06-2) → (E)-N,N-dimethyl-4-(1-phenyl-2-(pyrazin-2-yl)vinyl)aniline

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.7b03024

upstream raw materials:

2-Methylpyrazine

4-dimethylamino-benzaldehyde