2(1H)-Quinolinone, 3-acetyl-

Base Information

• Chemical Name: 2(1H)-Quinolinone, 3-acetyl-
• CAS No.: 50290-20-5
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.19500
• Mol file: 50290-20-5.mol

Synonyms:1,2-Dihydro-3-acetylquinolin-2-one;3-Acetyl-1H-chinolin-2-on;3-acetylcarbostyril;3-acetyl-1H-quinoline-2-one;

Chemical Property of 2(1H)-Quinolinone, 3-acetyl-

Chemical Property:

• PSA: 50.19000
• LogP: 2.14300

Purity/Quality:

99% ^*data from raw suppliers

3-Acetyl-1H-quinolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Quinolinone, 3-acetyl-

There total 3 articles about 2(1H)-Quinolinone, 3-acetyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-(2-formylphenyl)but-2-ynamide → 3-acetyl-1,2-dihydroquinolin-2-one (50290-20-5) + N-(2-formylphenyl)acetamide (13493-47-5)

Guidance literature:

With palladium diacetate; acetic acid; 5,5′-dimethoxy-2,2′-bipyridine; In 1,2-dichloro-ethane; at 80 ℃; Solvent; Reagent/catalyst; Temperature; Catalytic behavior; Molecular sieve; Inert atmosphere;

DOI:10.1055/s-0034-1380751

Reference yield: 70.0%

o-aminobenzaldehyde (529-23-7) + 1,3-dimethyl-5-pyrazolone (2749-59-9) → 3-acetyl-1,2-dihydroquinolin-2-one (50290-20-5) + 3-(2-quinolyl)carbostyril (58130-43-1) + 4-o-aminobenzylidene-1,3-dimethylpyrazolin-5-one (89522-25-8) + 1,3-dimethylpyrazolo<3,4-b>quinoline (89522-26-9)

Guidance literature:

at 150 ℃; Product distribution; Mechanism; at 260 degC;

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → 3-acetyl-1,2-dihydroquinolin-2-one (50290-20-5) + N-(2-formylphenyl)acetamide (13493-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: palladium diacetate; acetic acid; 5,5′-dimethoxy-2,2′-bipyridine / 1,2-dichloro-ethane / 80 °C / Molecular sieve; Inert atmosphere

With palladium diacetate; acetic acid; dicyclohexyl-carbodiimide; 5,5′-dimethoxy-2,2′-bipyridine; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1055/s-0034-1380751

upstream raw materials:

o-aminobenzaldehyde

1,3-dimethyl-5-pyrazolone

2-Aminobenzyl alcohol

Downstream raw materials:

2-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-thiazol-2-ylaminocarbonyl]-benzoic acid

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