Colchicine, 17-fluoro-

Base Information

• Chemical Name: Colchicine, 17-fluoro-
• CAS No.: 26195-68-6
• Molecular Formula: C₂₂H₂₄FNO₆
• Molecular Weight: 417.434
• NSC Number: 180259
• DSSTox Substance ID: DTXSID50180826
• ChEMBL ID: CHEMBL86029
• Mol file: 26195-68-6.mol

Synonyms:Fluorocolchicine;COLCHICINE, 17-FLUORO-;17-Fluorocolchicine;NSC 180259;BRN 2790210;26195-68-6;Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-;Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-;Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;NSC180259;CHEMBL86029;C22H24FNO6;DTXSID50180826;C22-H24-F-N-O6;NSC-180259;LS-54689

Chemical Property of Colchicine, 17-fluoro-

Chemical Property:

• Vapor Pressure: 2.34E-21mmHg at 25°C
• Boiling Point: 733.2°Cat760mmHg
• Flash Point: 397.2°C
• Density: 1.29g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 417.15876565
• Heavy Atom Count: 30
• Complexity: 761

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)CF
• Isomeric SMILES: COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)CF

Technology Process of Colchicine, 17-fluoro-

There total 2 articles about Colchicine, 17-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Fluoroacetic acid (144-49-0) + N-deacetylcolchicine trifluoroacetate (1415695-51-0) → 2-fluoro-N-{(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl}acetamide (26195-68-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.03.019

Reference yield:

→ N-Fluoracetyl-desacetylcolchicin (26195-68-6)

Guidance literature:

Desacetylcolchicin 1c, Fluoracetylchlorid;

DOI:10.1002/jlac.19727580120

upstream raw materials:

Fluoroacetic acid

N-deacetylcolchicine trifluoroacetate