Propanoic acid, 2,2-dimethyl-, 6-(4-fluorophenyl)-2,3-dihydro-7-[2-(methylthio)-4-pyrimidinyl]-5-oxo-1H, 5H-pyrazolo[1,2-a]pyrazol-2-yl ester

Base Information

• Chemical Name: Propanoic acid, 2,2-dimethyl-, 6-(4-fluorophenyl)-2,3-dihydro-7-[2-(methylthio)-4-pyrimidinyl]-5-oxo-1H, 5H-pyrazolo[1,2-a]pyrazol-2-yl ester
• CAS No.: 503072-71-7
• Molecular Formula: C22H23FN4O3S
• Molecular Weight: 442.514

Synonyms:

Chemical Property of Propanoic acid, 2,2-dimethyl-, 6-(4-fluorophenyl)-2,3-dihydro-7-[2-(methylthio)-4-pyrimidinyl]-5-oxo-1H, 5H-pyrazolo[1,2-a]pyrazol-2-yl ester

Chemical Property:

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Useful:

Technology Process of Propanoic acid, 2,2-dimethyl-, 6-(4-fluorophenyl)-2,3-dihydro-7-[2-(methylthio)-4-pyrimidinyl]-5-oxo-1H, 5H-pyrazolo[1,2-a]pyrazol-2-yl ester

There total 1 articles about Propanoic acid, 2,2-dimethyl-, 6-(4-fluorophenyl)-2,3-dihydro-7-[2-(methylthio)-4-pyrimidinyl]-5-oxo-1H, 5H-pyrazolo[1,2-a]pyrazol-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylsulfonyl-pyrimidine-4-carbonyl chloride (503072-59-1) + 2,2-dimethyl-propionic acid 1-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester (503072-69-3) → 2,2-dimethyl-propionic acid 6-(4-fluorophenyl)-7-(2-methylsulfanyl-pyrimidin-4-yl)-5-oxo-2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-2-yl ester (503072-71-7)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; In hexane; dichloromethane; ethyl acetate;

Reference yield:

2,2-dimethyl-propionic acid 6-(4-fluorophenyl)-7-(2-methylsulfanyl-pyrimidin-4-yl)-5-oxo-2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-2-yl ester (503072-71-7) → 2-(4-fluorophenyl)-6-hydroxy-3-(2-phenoxypyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one (503072-62-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform;

upstream raw materials:

2-methylsulfonyl-pyrimidine-4-carbonyl chloride

2,2-dimethyl-propionic acid 1-[2-(4-fluorophenyl)acetyl]-pyrazolidin-4-yl ester

Downstream raw materials:

2-(4-fluorophenyl)-6-hydroxy-3-(2-phenoxypyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one

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